Tosoh Bioscience GmbH - BPI Europe Newsroom

TOYOPEARL GigaCap DEAE - Pushing productivity of anion exchange steps

Press release   •   Apr 15, 2013 17:05 CEST

Tosoh Bioscience is introducing a new weak anion exchanger that offers a very high dynamic binding capacity while maintaining good peak resolution. Besides other applications this is of special interest for the purification plasma proteins.

TOYOPEARL GigaCap DEAE-650 is the newest member of the renowned TOYOPEARL GigaCap series of high capacity ion exchange media. The polymeric base bead was chemically modified to provide a high number of anionic binding sites for increased resin capacity. The typical dynamic binding capacity (DBC) of over 150 g/L for bovine serum albumin exceeds the DBC of all other commercial available DEAE chromatography media.The resin was proved to be stable for more than 100 cleaning-in-place (CIP) cycles with 0.5 M NaOH. Good mass transfer kinetics enable the resin to maintain DBC at faster linear velocities and leads to a narrow elution peak. This results in smaller and more concentrated in-process pool volumes, thus reducing the amount of water and buffer needed. The high capacity and low back pressure creates opportunities for increased throughput in various anion exchange purification steps and is ideally suited for efficient plasma protein purification.

Tosoh’s product portfolio encompasses GPC instruments and a comprehensive line of Toyopearl and TSKgel chromatography media and prepacked TSKgel HPLC columns. 

Tosoh Bioscience offers chromatography solutions for research, drug discovery, medicinal chemistry, environmental analysis, manufacturing and other industrial applications for all common modes of liquid chromatography, including IEC, HIC, RPC, HILIC, SEC and affinity.