Effective vaccine development and delivery is a never-ending challenge in the global biotechnology industry. The vaccine industry has evolved in the recent years to overcome the limitations of traditional vaccine delivery systems such as storage issues, lack of trained personnel, expiry of products etc. and to improve the overall efficacy and scalability of vaccines. This change is evident from the paradigm shift in the type of vaccines developed from the use of live or attenuated vaccines to the development of recombinant vector vaccines and DNA vaccines. There has been significant progress not only in the type of vaccines administered but also in the vaccine delivery systems which have experienced modifications from traditional syringes to throughput systems of multi-dose needle-free injectors and prefilled devices.
With non invasive oral routes already traversed in the delivery of some of the very successful vaccines like Sabin oral polio and the rotavirus vaccines, the researchers and industry players are now striking novelty in vaccines towards needle- free delivery which would help simplify immunization and allow self administration. According to a recent study by RNCOS, there have already been significant advancements in this domain which include development of Aerosol Immunization and inhalable vaccines, Microneedle vaccine delivery and the use of pollen grains and nanotechnology in a technology called PRINT (Particle Replication in Non-wetting Templates) for miniaturization and improvisation in the efficacy of the administered vaccines.
Anticipating an upsurge of opportunities if the vaccine delivery systems progress with the existing pace, Shushmul Maheshwari, Chief Executive, RNCOS said that Global vaccine industry in near times will witness a dynamic shift from a syringe and a vial to tech-savvy gadgets and miniaturized delivery systems which would ultimately lead to faster eradication of diseases and an era of equitable health. Achieving this, however, will be at the discretion of the parallelism between market players and researchers that will largely determine the reshaping of the vaccine industry.
Novel vaccine delivery systems will not only address basic vaccine administration issues but also improve dose efficacy. Nanotechnology in particular carries great hope for high-throughput vaccine delivery systems with market players already exploring the field especially for nano-scale skin patches to tap the promising market of next generation vaccine delivery systems.
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