Dec 5, 2013 : Bharat Book Bureau presents the new report, on ''The Engineered T-Cell Receptor in Fusion Proteins, Antibodies & Cells: Emerging Opportunities for the Biopharmaceutical Industry" describes chances and pitfals in exploiting the opportunities which offers the engineered T-cell receptor as integral part of fusion proteins, antibodies and cellular products.
A comparative analysis and assessment of TCR technologies, pipelines and
companies from an industry perspective
Therapeutic monoclonal antibodies have become an increasingly successful treatment modality with sales of US$ 65 bln in the year 2012 and with an average (continuous) annual growth rate from 2006 to 2012 of 18.9%. While antibody technologies are steadily evolving, the spectrum of druggable targets for monoclonal antibodies has remained limited to extracellular antigens, albeit including proteins, carbohydrates and glycolipids.
Access to druggable, IP-protected and validated new targets is a major
bottleneck in the biopharmaceutical industry. Technologies which can deliver
both new targets and the corresponding treatment modality, can expect
significant financial acknowledgement.
The T-cell receptor (TCR) has recently emerged as a means to target peptide antigens derived from intracellular proteins, however, in a major histocompatibility complex (MHC)-restricted manner. The first companies have overcome significant technical hurdles in putting together a library of viable new TCR-targeted antigens and establish the corresponding standardized protein- and cell-based therapeutic frameworks.
This report entitled „The Engineered T-Cell Receptor in Fusion Proteins, Antibodies & Cells: Emerging Opportunities for the Biopharmaceutical Industry“ published in Ocotber 2013 describes chances and pitfals in exploiting the opportunities which offers the engineered T-cell receptor as integral part of fusion proteins, antibodies and cellular products. The key success factors are highlighted, the technical challenges described and solutions presented.
Benefits from the report:
Identify players in the field, from industry and academia;
Find out which TCR technologies are valued by Big Pharma and Biotech;
Understand the value of intracellular antigens targeted by the TCR;
Recognize the challenges of TCR-based therapeutics and their solutions;
Learn which TCR-based therapeutics are attractive for partnering;
Find out which TCR therapeutic approaches are not yet tapped.
Table of Contents
0. List of Abbreviations
1. Executive Summary
3. The T-Cell Receptor
4. TCR Fusion Proteins
4.1 Altor Bioscience
4.1.2 Financing history
4.1.3 IP protection
4.1.5 STAR technology
4.1.6 Binding affinity of scTCRs
4.1.7 Manufacturing of STAR molecules
4.1.8 Targets for scTCRs
4.1.9 Generation of scTCRs
4.1.10 Other applications of STAR molecules
4.1.11 STAR pipeline
220.127.116.11 Preclinical characterization of ALT-801
18.104.22.168 Clinical results of studies with ALT-801
22.214.171.124 Ongoing clinical studies with ALT-801
126.96.36.199 Safety of ALT-801 in clinical studies
188.8.131.52 Clinical immunogenicity of ALT-801
184.108.40.206 Clinical pharmacokinetics of ALT-801
4.2.1 Corporate development of Immunocore
4.2.2 Stability and solubility of TCRs
4.2.3 Affinity of monoclonal TCRs (mTCR)
4.2.4 Effector function for mTCR
4.2.5 Target discovery for mTCRs
4.2.6 Preclinical experience with mTCRs
4.2.7 ImmTAC clinical lead program
For more information kindly visit : http://www.bharatbook.com/healthcare-market-research-reports/the-engineered-t-cell-receptor-in-fusion-proteins-antibodies-cells-emerging-opportunities-for-the-biopharmaceutical-industry.html
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