2012-04-04 09:24 Three different experimental approaches were used for obtaining a comprehensive view and understanding of the interactions between apolipoprotein B-100 (ApoB-100) of low-density lipoprotein and apolipoprotein E (ApoE) of high-density lipoprotein and chondroitin-6-sulfate (C6S) of arterial proteoglycan. Read the full abstract here: www.attana.com/pub_antibodies_proteins

2012-03-28 09:17 The photoinitiated radical reactions between thiols and alkenes/alkynes (thiol-ene and thiol-yne chemistry) have been applied to a functionalization methodology to produce carbohydrate-presenting surfaces for analyses of biomolecular interactions. Read the full abstract here: www.attana.com/pub_carbohydrates

2012-03-06 09:00 Single-walled carbon have properties that make them useful for drug delivery, and their photo-thermal effects make them potentially useful in a wide range of applications, particularly the treatment of solid tumors. Follow link for full abstract: www.attana.com/pub_cells. See abstract on video (Attana Cell 200 data shown in min 04:55) http://www.dovepress.com/articles.php?article_id=9317

2011-07-14 08:24 Wiklander et al: A series of streptavidin-mimicking molecularly imprinted polymers has been developed and evaluated for their biotin binding characteristics. A combination of radioligand binding studies and surface area analyses demonstrated the presence of selectivity in polymers prepared using methacrylic acid as the functional monomer. See link for full abstract! -->

2011-07-06 10:25 Dahlbäck et al: During pregnancy, the interaction between malaria infected erythrocytes and the placental receptor is mediated by the parasite expressed protein VAR2CSA. A vaccine against placental malaria should induce antibodies inhibiting the interaction between VAR2CSA and CSA. In this study, we used a biosensor technology to examine binding properties... see link for full article! -->

2011-05-30 09:05 University of Stuttgart, Institute of Cell Biology and Immunology: A humanized IgG1 version (ATROSAB) of a murine TNFR1-selective antagonistic antibody (H398) has been generated. The ATROSAB shows identical binding characteristics and sub-nanomolar affinity to both human and rhesus TNFR1.

2011-06-01 09:03 To facilitate the study of carbohydrate-protein interactions a method for label-free measurements has been developed using the Attana 100 biosensor to monitor binding events in real time. The method relies on measurement of the inhibition of a well-known carbohydrate-lectin binding pair, Concanavalin A - Yeast mannan, by lectin binding carbohydrates.

2011-05-24 09:00 Attana Cell 200 - Bridging the gap between traditional biosensors and cell-based assays! Drug development is costly and risky and the need for technologies that accelerate the process of drug discovery becomes increasingly urgent. This paper shows four instances of how the Attana Cell 200 biosensor provides data enhancing the ability to select the right drug candidates earlier in the process.

2011-04-18 09:52 The data obtained from QCM analyses are firstly qualitative, delivering information about specificity and selectivity, and quantitative, delivering exact thermodynamic and kinetic parameters of interactions. See the difference in this poster!

2011-04-13 08:58 Attana has several Quartz Crystal Microbalance (QCM) based instruments and applications, all catering to crucial needs and developed in close collaboration with industry and universities. Examples include kinetic analysis on cell surfaces, candidate selection screening, aggregation characterization, epitope mapping and concentration determination of biopharmaceuticals.