Dokument

Attana Application Note: Characterization of complex lectin-cell kinetics

2010-06-23 08:46

The objective of this application note was to determine the binding properties of the lectin ConA towards human epidermoid carcinoma cells. Among other things it was found that a kinetic approach may be used to determine the apparent affinity and rate constants of lectin-cell glycan interactions, providing a greater understanding of the mechanism involved in the lectin recognition of cancer cells.

Ladda ner

Pdf Ladda ner dokumentet

Creative Commons erkännande

Kategorisering

Ämnen:
Medicin,
Medicinsk forskning,
Vetenskap, teknik
Tags:
cell,
attana cell 200,
biosensor

Relaterade pressmeddelanden

Biosensor- Attana Cell 200, label free, real time kinetics on cells

Biosensor- Attana Cell 200, label free, real time kinetics on cells

2010-02-01 14:36 Revolutionary Swedish invention can potentially improve drug development! Attana AB introduces the Attana Cell 200 – the first system to permit real-time kinetic analysis of molecular interactions directly on cell surfaces, bringing drug development a step closer to the body.

Se fler (1)

Relaterade nyheter

PEGS 2011 with Attana!

PEGS 2011 with Attana!

2011-05-23 09:00 We are pleased to have met so many like minded members of industry during the Protein Engineering Summit 2011 in Boston last week. If you were there but didn't get the chance to taste our exquisite espresso you are always welcome to stop by our booth during our upcoming events!

Maximising Drug Discovery Research- Interview with Attana CEO, Teodor Aastrup

Maximising Drug Discovery Research- Interview with Attana CEO, Teodor Aastrup

2010-12-22 04:30 Attana is one of the sponsor companies at the upcoming marcus evans Discovery Summit 2011 in Cannes, France, 21-23 March. Prior to the event marcus evans and Aastrup discuss in this interview the role biologics can play in speeding up drug discovery and subsequent stages.

Fight against cancer - Attana's collaborator interviewed

Fight against cancer - Attana's collaborator interviewed

2010-09-22 15:34 Attana's collaborator at Gothenburg University, Dr. Sture Lindegren, is interviewed about a possible new cure for ovarian cancers. Using the Attana Cell 200 instrument, Dr. Lindegren and his team are testing antibodies as carriers of radionuclide that target cancer cells directly instead of affecting the whole body as current cancer therapies do.

Fight against cancer - Attana's collaborator interviewed

Fight against cancer - Attana's collaborator interviewed

2010-09-14 15:30 Attana's collaborator at Gothenburg University, Dr. Sture Lindegren, is interviewed about a possible new cure for ovarian cancers. Using the Attana Cell 200 instrument, Dr. Lindegren and his team are testing antibodies as carriers of radionuclide that target cancer cells directly instead of affecting the whole body as current cancer therapies do.

Attana's Story told by CEO and co-founder Dr. Teodor Aastrup

Attana's Story told by CEO and co-founder Dr. Teodor Aastrup

2010-07-05 15:49 When we founded Attana in 2002, we had a dream of creating a tool that could mimic reality. We were set to do this by developing an instrument capable of measuring biological interactions exactly as the actual events in the human body.

PEGS 2010 with Attana!

PEGS 2010 with Attana!

2010-06-02 16:06 We are happy to have met so many industry people during the Protein Engineering Summit 2010 in Boston last week, and if you were there but didn't get the chance to taste our exquisite espresso you are welcome to stop by our booth during our upcoming events!

PEGS 2010 with Attana!

PEGS 2010 with Attana!

2010-06-02 10:15 We are happy to have met so many industry people during the Protein Engineering Summit 2010 in Boston last week, and if you were there but didn't get the chance to taste our exquisite espresso you are welcome to stop by our booth during our upcoming events!

The Story of Attana - told by CEO and co-founder, Dr. Teodor Aastrup

The Story of Attana - told by CEO and co-founder, Dr. Teodor Aastrup

2009-11-12 21:19 When we founded Attana in 2002, we had a dream of creating a tool that could mimic reality. We were set to do this by developing an instrument capable of measuring biological interactions exactly as the actual events in the human body.

Se fler (8)

Relaterade evenemang

Discovery 2010

Discovery 2010

2010-08-20 09:18 Teodor Aastrup, CEO , Attana AB will be presenting on: Kinetics on cells – bridging the gap between traditional biosensors and cell-based assays The development of new pharmaceutical antibodies is a long and expensive process with sharply increasing costs during clinical trials. Widespread technologies to measure molecular interactions using purified target and ligand are powerful, but of...

Tid: 2010-09-19 - 2010-09-21
Plats: Red Rock Casino Resort Spa, Las Vegas, USA

Understanding kinetics - Attana Step II Course

Understanding kinetics - Attana Step II Course

2010-03-16 10:00 Welcome to Attana Step II Course - Training! Course Introduction This course is designed to increase your knowledge on how the Attana instrument can be used to solve problems and increase efficiency with regards to running and developing assays. The course is also aimed at giving a deeper understanding of concepts such as kinetics, active concentration, mass transport, avidity and more. I...

Tid: 2010-09-27 - 2010-09-29
Plats: Stockholm, Sweden

Next Generation Protein Therapeutics

Next Generation Protein Therapeutics

2010-08-19 11:02 Spotlight Presentation 29th September, 10.15 : Real Time Cell Surface Interaction Analysis Dr. Miriam Dwek , Senior Lecturer in Biochemistry, Department of Molecular & Applied Biosciences, University of Westminster will present drug conjugate data using the Attana Cell 200 – the first system to permit real-time kinetic analysis of molecular interactions directly on cell surfaces, bridging ...

Tid: 2010-09-28 - 2010-09-29
Plats: Sheraton Brussels Hotel Brussels, Belgium

Attana Kinetic Concepts Course

2010-10-26 10:10 Attana offers a Kinetic Concepts course! Due to popular demand we have scheduled an extra Kinetic Concepts course in November - if you haven't already signed up, you better hurry! The course is designed to increase your understanding of concepts related to molecular interactions, and gives a deeper knowledge of how these concepts can be applied to biosensor assays as well as providing a s...

Tid: 2010-11-17 - 2010-11-18
Plats: Attana, Stockholm, Sweden

European Antibody Engineering

European Antibody Engineering

2010-09-01 08:40 Attana will be exhibiting at booth #17- stop by to see our instrument and find out more about our applications and products!

Tid: 2010-11-29 - 2010-12-01
Plats: Geneva, Switzerland

European Antibody Engineering

European Antibody Engineering

2010-09-01 16:49 Attana will be there, will you? More information to come!

Tid: 2010-11-29 - 2010-12-01
Plats: Geneva, Switzerland

Attana at Antibody Engineering

Attana at Antibody Engineering

2010-09-08 08:52 Attana will exhibit at booth #216- come see The Attana Cell 200 instrument! Tuesday December 7 at 1:45-2:45 - Attana's CEO Dr. Teodor Aastrup will host a technology workshop on "Kinetics on Cells - Bridging the gap between traditional biosensors and cell based assays". Measuring the kinetic properties of biomolecules has become increasingly important in drug discovery, vaccine production and...

Tid: 2010-12-05 - 2010-12-09
Plats: San Diego, USA

Antibody Engineering

Antibody Engineering

2010-09-08 15:45 Attana will be there, will you? More information to come! Event web page: www.ibclifesciences.com/antibodyeng/overview.xml

Tid: 2010-12-05 - 2010-12-09
Plats: San Diego, USA

Attana at Antibody Engineering & Design

Attana at Antibody Engineering & Design

2011-02-18 10:57 Join our panel discussion- Wed 23rd @ 16.40 Biologically relevant information- improving success of clinical trials! Panelists: Dr Teodor Aastrup, CEO, Attana Dr Juan Carlos Almagro, Research Fellow, Head, Antibody Design Unit, Centocor Dr Jesus Zurdo, Head of Innovation LCM Development Services, Lonza Dr Alain Beck, Head of Physico Chemistry, Centre d'Immunologie Pierre Fabre ...

Tid: 2011-02-22 - 2011-02-24
Plats: InterCity Hotel, Frankfurt

International Congress of Antibodies (ICA 2011)

International Congress of Antibodies (ICA 2011)

2011-03-07 09:00 Attana will be participating at the International Congress of Antibodies in Beijing and present on several topics: "In Vitro Evolution of Allergy Vaccine Candidates with Reduced IgE-Binding and T-Cell Activation Capacity" - Ola B Nilsson and the Karolinska Institute "Kinetics on Cells - Bridging the Gap Between Traditional Biosensors and Cell-Based Assays" - Samuel Altun, Cell Application...

Tid: 2011-03-23 - 2011-03-25
Plats: Beijing, China

Attana at World Immune Regulation Meeting!

2011-01-14 09:18 Attana will be there, will you?

Tid: 2011-03-24 - 2011-03-27
Plats: Davos, Switzerland

Attana Kinetics on Cells Course!

Attana Kinetics on Cells Course!

2011-04-19 09:00 Discover what really happens at the cell surface - Attend the Attana Kinetics on Cells course! • A biosensor - Reveals full kinetics • Cell based assays - Disclose the entire cell surface environment • The Attana kinetics on cells course - Demonstrates the value of combining them! Bridging the gap between biosensors and cell based assays! When: 26-27 October 2011 Price: 15...

Tid: 2011-10-26 - 2011-10-27
Plats: Stockholm, Sweden

Se fler (12)

Relaterade bilder

Attana Cell Sensor Chip

Attana Cell Sensor Chip

2010-06-14 10:02 The Attana cell sensor chip with the cultivation lid and cell suspension added.

Attana Cell 200 biosensor- Label free, real time kinetics on cells

Attana Cell 200 biosensor- Label free, real time kinetics on cells

2010-02-22 10:05 Cell and biochemical assays Analyte/ligand types: - Adherent cells - Suspension cells - Fixed and non-fixed cells - Crude samples - Proteins, antibodies, carbohydrates - Viruses, bacteria Applications: - Kinetics on cells - Cell capturing - Detailed kinetics - Concentration determination - Competition assay - Epitope mapping - Off-rate selection - Aggregation characterization

Se fler (2)

Relaterade videor

Attana Cell Biosensor

Attana Cell Biosensor

2011-01-14 09:00 The Attana Cell 200 biosensor has the unique ability to determine label-free kinetics directly on the cell surface, therefore disclosing the full complexity of the interaction at a very early stage. By delivering biologically relevant information this early in the research process, The Attana Cell 200 minimizes costs and increases success during clinical trials.(produced by TTV AB)
Längd  1:24

Se fler (1)

Relaterade dokument

Molecular Interaction Studies in Cells: Exploring Biology at a New Level

2011-01-26 08:53 The journal IPT features an article written by Attana's product manager where he discusses how to achieve biological relevance during research and the benefits of doing so. The article is also available online, see right for link.

Kinetics on Cells - Attana poster

2010-11-11 09:02 Kinetics on cells using the Attana Cell 200 - two application examples easily explained in Attana's new poster. Select the right candidate early by getting biologically relevant data from interactions directly on the cell surface.

Attana Application Note: Crude samples analysis - Direct off-rate screening in supernatants and lysates

2010-07-14 09:07 The objective of this application note was to determine off-rates of antibodies in mouse hybridoma supernatants and scaffold proteins in bacterial lysates using the Attana 200 system and Low Non-specific Binding (LNB) surfaces. Among other things, a method that can be used for clone selection, vaccine screening, biomarker discovery, biomanufacturing and performance studies was developed.

Attana Application Note: Crude samples analysis - Screening and characterization of hybridoma supernatants

2010-06-30 09:58 The objective of this application note was primarily to screen mouse IgG antibodies from crude samples for dissociation rates of bound antigen, and to determine detailed kinetic rate constants between the antigen and an antibody selected in the screen. Among other things, a method to capture mouse IgG from hybridoma supernatants was developed which can be replicated for capture of human IgGs.

Attana Application Note: Early detection of clinical failure

2010-06-16 09:42 The objective of this application note was to evaluate newly developed therapeutic antibodies in a biologically relevant context (cells) in order to detect failing candidates at an earlier stage. Among other things, it was found that real-time screening of drug candidates in a synthetic and in a cellular context together provides highly informative and biologically relevant data.

Attana Application Note: Glycosylation profile of cancer cells

2010-06-09 08:34 The objective of this application note was to determine the glycosylation profile of cancer cells using a cell based QCM Biosensor assay. Among other things, it was found that a single surface can be used to perform lectin screening and to provide a highly relevant and reproducible determination of the glyco-profile of cancer cells.

Scientific publications pertaining to the Attana systems

2010-06-04 08:22 A list of publications where the Attana systems have been utilized. The publications relate to various species such as glycovesicles, antibodies, proteins, nanobodies and more.

Se fler (7)

Kommentarer (0)

Lägg till kommentar