2011-07-11 08:59 Lund University: Molecularly imprinted polymers (MIPs) were prepared in situ on Attana's quartz crystal sensor surface with good reproducibility and long-term stability. The resulting MIP surfaces can be used for detection and discrimination between very similar molecules, and the analysis is fast enough to allow for large amounts of samples.

2011-06-22 08:44 University of California, San Fransisco (UCSF): A method has been optimized to extract Botulinum toxin A from the inclusion body, refold it into active form and purify it using ion exchange chromatography. A rapid immunoassay was also developed to facilitate monitoring of active Botulinum toxin A during purification, using Attana's quartz crystal microbalance sensor technology.

2011-06-20 08:28 Two experiments with two distinct purposes were performed on the Attana Cell 200. The first experiment intended to find a diagnostic tool to test tumors after surgery to see if they are metastatic. The second experiment tested a herceptin conjugate designed for targeted immunotherapy. Both results showed that the Attana Cell 200 may help lowering clinical stage failure rates.

2011-05-27 09:12 Attana and Layerlab: Lipoparticles containing a CXCR4 chemokine receptor were immobilized using memLAYER on the Attana LNB Carboxyl chip. The applicability of lipoparticles and memLAYER for functional studies of GPCRs on the Attana A200 biosensor are demonstrated as well as the benefits of the memLAYER-immobilization.

2011-05-30 09:05 University of Stuttgart, Institute of Cell Biology and Immunology: A humanized IgG1 version (ATROSAB) of a murine TNFR1-selective antagonistic antibody (H398) has been generated. The ATROSAB shows identical binding characteristics and sub-nanomolar affinity to both human and rhesus TNFR1.

2011-06-01 09:03 To facilitate the study of carbohydrate-protein interactions a method for label-free measurements has been developed using the Attana 100 biosensor to monitor binding events in real time. The method relies on measurement of the inhibition of a well-known carbohydrate-lectin binding pair, Concanavalin A - Yeast mannan, by lectin binding carbohydrates.

2011-04-13 08:58 Attana has several Quartz Crystal Microbalance (QCM) based instruments and applications, all catering to crucial needs and developed in close collaboration with industry and universities. Examples include kinetic analysis on cell surfaces, candidate selection screening, aggregation characterization, epitope mapping and concentration determination of biopharmaceuticals.