2011-07-14 08:24 Wiklander et al: A series of streptavidin-mimicking molecularly imprinted polymers has been developed and evaluated for their biotin binding characteristics. A combination of radioligand binding studies and surface area analyses demonstrated the presence of selectivity in polymers prepared using methacrylic acid as the functional monomer. See link for full abstract! -->

2011-07-06 10:25 Dahlbäck et al: During pregnancy, the interaction between malaria infected erythrocytes and the placental receptor is mediated by the parasite expressed protein VAR2CSA. A vaccine against placental malaria should induce antibodies inhibiting the interaction between VAR2CSA and CSA. In this study, we used a biosensor technology to examine binding properties... see link for full article! -->

2011-06-06 08:42 Lonza: This poster shows how the Lonza Biologics AggreSolve platform has been expanded and successfully applied to engineer humanized antibodies with good developability profiles; such antibodies have good stability, productivity and retain activity of therapeutic levels, eliminating the need for further, potentially destabilizing, affinity maturation.

2011-05-30 09:05 University of Stuttgart, Institute of Cell Biology and Immunology: A humanized IgG1 version (ATROSAB) of a murine TNFR1-selective antagonistic antibody (H398) has been generated. The ATROSAB shows identical binding characteristics and sub-nanomolar affinity to both human and rhesus TNFR1.

2011-06-01 09:03 To facilitate the study of carbohydrate-protein interactions a method for label-free measurements has been developed using the Attana 100 biosensor to monitor binding events in real time. The method relies on measurement of the inhibition of a well-known carbohydrate-lectin binding pair, Concanavalin A - Yeast mannan, by lectin binding carbohydrates.

2011-01-26 08:53 The journal IPT features an article written by Attana's product manager where he discusses how to achieve biological relevance during research and the benefits of doing so. The article is also available online, see right for link.

2010-11-11 09:02 Kinetics on cells using the Attana Cell 200 - two application examples easily explained in Attana's new poster. Select the right candidate early by getting biologically relevant data from interactions directly on the cell surface.

2010-06-04 15:16 A list of publications where the Attana systems have been utilized. The publications relate to various species such as glycovesicles, antibodies, proteins, nanobodies and more.

2010-07-14 09:07 The objective of this application note was to determine off-rates of antibodies in mouse hybridoma supernatants and scaffold proteins in bacterial lysates using the Attana 200 system and Low Non-specific Binding (LNB) surfaces. Among other things, a method that can be used for clone selection, vaccine screening, biomarker discovery, biomanufacturing and performance studies was developed.

2010-06-30 09:58 The objective of this application note was primarily to screen mouse IgG antibodies from crude samples for dissociation rates of bound antigen, and to determine detailed kinetic rate constants between the antigen and an antibody selected in the screen. Among other things, a method to capture mouse IgG from hybridoma supernatants was developed which can be replicated for capture of human IgGs.

2010-06-30 16:25 The objective of this application note was primarily to screen mouse IgG antibodies from crude samples for dissociation rates of bound antigen, and to determine detailed kinetic rate constants between the antigen and an antibody selected in the screen. Among other things, a method to capture mouse IgG from hybridoma supernatants was developed which can be replicated for capture of human IgGs.

2010-07-14 16:19 The objective of this application note was to determine off-rates of antibodies in mouse hybridoma supernatants and scaffold proteins in bacterial lysates using the Attana 200 system and Low Non-specific Binding (LNB) surfaces. Among other things, a method that can be used for clone selection, vaccine screening, biomarker discovery, biomanufacturing and performance studies was developed.

2010-06-04 08:22 A list of publications where the Attana systems have been utilized. The publications relate to various species such as glycovesicles, antibodies, proteins, nanobodies and more.