GöteborgBIO and Biomaterials Research Centre invite you to:

Biomaterialomics —From Molecular Interactions to Human Benefits

The Japanese Professor Tatsuo Suda, who discovered a part of vitamin D3, visits Göteborg this week. At the seminar "Biomaterialomics - From Molecular Interaction to Human Benefits" on Thursday November 25, he will lecture and show a new concept on vitamin D action in bone. GöteborgBIO and Biomaterials Research Centre organise the event, taking place at Conf. Centre Wallenberg.

Seminar
We promise a day full of the most interesting lectures related to "the smallest important details for our well being" from both international and national speakers. Professor Suda, who discovered vitamin D3, explores the molecular mechanisms in relation to bone. This theme is further developed by Professor Lerner who will discuss steroids and bone remodeling. Dr Wong explores gene expression techniques and Dr Omar highlights the titanium-tissue interface. We will also get insight in how data can be explored in a “novel and easy to use way" with Qlucore software by Mr Ivarsson.

Lecture Abstract Professor Suda on November 25: The Role of Vitamin D in Bone.

 Tatsuo Suda, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan

 Vitamin D was discovered as an anti-rachitic agent to stimulate bone growth and mineralization, but there is no evidence even nowadays that vitamin D directly stimulates bone growth and mineralization by osteoblasts. On the contrary, its metabolically active form [1α,25(OH)₂D₃] has been known to be one of the most potent factors to induce osteoclast differentiation factor (ODF)/ receptor activator of NF-kB (RANKL) in osteoblasts in vitro. RANKL is an essential factor to induce osteoclast formation in the presence of M-CSF.  Irrespective of that, it has been reported that long-term in vivo administration of 1α,25(OH)₂D₃ or its synthetic analog [1α(OH)D₃] increases bone mass by preventing bone resorption. Recent in vivo research on vitamin D and bone has given an important clue to solve these discrepancies between in vivo and in vitro. (1) Cell cycle-arrested quiescent osteoclast precursors have been identified. (2)Osteoclast precursors migrate from bone / bone marrow into blood stream and come back again to the fixed bone surface attracted by some chemokines. (3) Osteoblasts have a chemotactic factor to attract osteoclast precursors, besides RANKL and M-CSF.  It is likely that there are some similarities between osteoclastogenesis and osseointegration.  In my talk, I will show a new concept on vitamin D action in bone.

Moderator is Margareta William-Olsson, well-known medical reporter, with great experience from the area of life science.

Picture: Professor Tatsuo Suda

Contact Information:

 For questions regarding the programme:
Carina Johansson, Biomaterials Research Centre, Chair.
carina.johansson@oru.se, mobiile phone 0739 881920

For questions regarding registration:
Marja Janusson, GöteborgBIO
marja.janusson@goteborgbio.se, phone number 031- 61 55 57