http://www.mynewsdesk.com/se/pressroom/attana-ab/document/list Mynewsdesk nyhetsfeed direkt från källan http://www.mynewsdesk.com/se/pressroom/attana-ab/document/list http://www.mynewsdesk.com/images/redesign/graphics/logos/logo-small.png 128 23 sv 15 Thu, 14 Jul 2011 08:24:00 +0200 Wiklander et al: A series of streptavidin-mimicking molecularly imprinted polymers has been developed and evaluated for their biotin binding characteristics. A combination of radioligand binding studies and surface area analyses demonstrated the presence of selectivity in polymers prepared using methacrylic acid as the functional monomer. See link for full abstract! --> http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/towards-a-synthetic-avidin-mimic-14630?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/towards-a-synthetic-avidin-mimic-14630?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document Attana AB Mon, 11 Jul 2011 08:59:00 +0200 Lund University: Molecularly imprinted polymers (MIPs) were prepared in situ on Attana's quartz crystal sensor surface with good reproducibility and long-term stability. The resulting MIP surfaces can be used for detection and discrimination between very similar molecules, and the analysis is fast enough to allow for large amounts of samples. http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/mip-thin-films-on-quartz-crystal-microbalance-14126?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/mip-thin-films-on-quartz-crystal-microbalance-14126?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document Attana AB Wed, 06 Jul 2011 10:25:00 +0200 Dahlbäck et al: During pregnancy, the interaction between malaria infected erythrocytes and the placental receptor is mediated by the parasite expressed protein VAR2CSA. A vaccine against placental malaria should induce antibodies inhibiting the interaction between VAR2CSA and CSA. In this study, we used a biosensor technology to examine binding properties... see link for full article! --> http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/the-chondroitin-sulfate-a-binding-site-of-the-var2csa-protein-involves-multiple-n-terminal-domains-14627?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/the-chondroitin-sulfate-a-binding-site-of-the-var2csa-protein-involves-multiple-n-terminal-domains-14627?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document Attana AB Tue, 28 Jun 2011 17:05:44 +0200 Lonza and Attana in collaboration: The combination of computational and protein engineering tools with novel orthogonal methods of measuring aggregation can be used to assess the developability of biopharm products in the early stages of development, thereby reducing the level of risk in later stages. http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/improving-the-developability-of-biopharmaceuticals-14524?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/improving-the-developability-of-biopharmaceuticals-14524?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document Attana AB Wed, 22 Jun 2011 08:44:00 +0200 University of California, San Fransisco (UCSF): A method has been optimized to extract Botulinum toxin A from the inclusion body, refold it into active form and purify it using ion exchange chromatography. A rapid immunoassay was also developed to facilitate monitoring of active Botulinum toxin A during purification, using Attana's quartz crystal microbalance sensor technology. http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/large-scale-production-of-botulium-neurotoxin-type-a-binding-domain-and-characterization-by-quartz-crystal-microbalance-biosensor-technology-14123?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/large-scale-production-of-botulium-neurotoxin-type-a-binding-domain-and-characterization-by-quartz-crystal-microbalance-biosensor-technology-14123?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document Attana AB Mon, 20 Jun 2011 08:28:00 +0200 Two experiments with two distinct purposes were performed on the Attana Cell 200. The first experiment intended to find a diagnostic tool to test tumors after surgery to see if they are metastatic. The second experiment tested a herceptin conjugate designed for targeted immunotherapy. Both results showed that the Attana Cell 200 may help lowering clinical stage failure rates. http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/kinetics-on-cells-bridging-the-gap-between-biosensors-and-cell-based-assays-14121?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/kinetics-on-cells-bridging-the-gap-between-biosensors-and-cell-based-assays-14121?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document Attana AB Wed, 15 Jun 2011 08:25:00 +0200 Massachusetts Institute of Technology (MIT): A biocompatible and injectable designer self-assembling peptide hydrogel system has been developed. It may be a useful carrier for the presentation of functional proteins and therapeutic antibodies for sustained release applications. http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/injectable-self-assembling-peptide-hydrogel-for-tissue-specific-controlled-release-applications-of-functional-proteins-14119?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/injectable-self-assembling-peptide-hydrogel-for-tissue-specific-controlled-release-applications-of-functional-proteins-14119?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document Attana AB Mon, 13 Jun 2011 08:43:00 +0200 Polypure: By using functionalized PEG derivatives, gold particles can be modified or conjugated to biomolecules to increase the stability. Avidin has been used as a tetrameric multivalent "glue" to demonstrate cluster formation between biotinylated AuNPEGs (Polyethylene glycol coated gold nanoparticles). http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/functionalized-peg-gold-nanoparticles-aunpegs-with-excellent-resistance-towards-agglomeration-14108?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/functionalized-peg-gold-nanoparticles-aunpegs-with-excellent-resistance-towards-agglomeration-14108?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document Attana AB Wed, 08 Jun 2011 08:31:00 +0200 Swiss Institute of Allergy and Asthma Research (SIAF): Currently we are using QCM to replace classical surface plasmon resonance experiments to quantify molecular interactions. We aim to establish this novel technology of measuring the interaction of biomolecules with molecules on entire cells, and to elucidate the binding properties of these interactions on defined systems. http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/evaluation-of-novel-quartz-crystal-microbalance-based-technologies-to-quantify-interactions-of-biological-macromolecules-with-cell-bound-markers-14105?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/evaluation-of-novel-quartz-crystal-microbalance-based-technologies-to-quantify-interactions-of-biological-macromolecules-with-cell-bound-markers-14105?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document Attana AB Mon, 06 Jun 2011 08:42:00 +0200 Lonza: This poster shows how the Lonza Biologics AggreSolve platform has been expanded and successfully applied to engineer humanized antibodies with good developability profiles; such antibodies have good stability, productivity and retain activity of therapeutic levels, eliminating the need for further, potentially destabilizing, affinity maturation. http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/engineering-humanisation-of-antibodies-with-good-developability-profiles-13953?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/engineering-humanisation-of-antibodies-with-good-developability-profiles-13953?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document Attana AB Wed, 01 Jun 2011 09:03:00 +0200 To facilitate the study of carbohydrate-protein interactions a method for label-free measurements has been developed using the Attana 100 biosensor to monitor binding events in real time. The method relies on measurement of the inhibition of a well-known carbohydrate-lectin binding pair, Concanavalin A - Yeast mannan, by lectin binding carbohydrates. http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/biosensor-competition-study-of-protein-carbohydrate-interactions-13949?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/biosensor-competition-study-of-protein-carbohydrate-interactions-13949?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document Attana AB Mon, 30 May 2011 09:05:00 +0200 University of Stuttgart, Institute of Cell Biology and Immunology: A humanized IgG1 version (ATROSAB) of a murine TNFR1-selective antagonistic antibody (H398) has been generated. The ATROSAB shows identical binding characteristics and sub-nanomolar affinity to both human and rhesus TNFR1. http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/atrosab-a-humanized-antagonistic-anti-tumor-necrosis-factor-receptor-one-specific-antibody-13946?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/atrosab-a-humanized-antagonistic-anti-tumor-necrosis-factor-receptor-one-specific-antibody-13946?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document Attana AB Fri, 27 May 2011 09:12:00 +0200 Attana and Layerlab: Lipoparticles containing a CXCR4 chemokine receptor were immobilized using memLAYER on the Attana LNB Carboxyl chip. The applicability of lipoparticles and memLAYER for functional studies of GPCRs on the Attana A200 biosensor are demonstrated as well as the benefits of the memLAYER-immobilization. http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/a-biosensor-based-concept-for-antibody-gpcr-interaction-studies-using-immobilized-lipoparticles-13944?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/a-biosensor-based-concept-for-antibody-gpcr-interaction-studies-using-immobilized-lipoparticles-13944?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document Attana AB Tue, 24 May 2011 09:00:00 +0200 Attana Cell 200 - Bridging the gap between traditional biosensors and cell-based assays! Drug development is costly and risky and the need for technologies that accelerate the process of drug discovery becomes increasingly urgent. This paper shows four instances of how the Attana Cell 200 biosensor provides data enhancing the ability to select the right drug candidates earlier in the process. http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/label-free-cell-based-biosensors-attana-cell-200-13884?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/label-free-cell-based-biosensors-attana-cell-200-13884?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document Attana AB Mon, 18 Apr 2011 09:52:00 +0200 The data obtained from QCM analyses are firstly qualitative, delivering information about specificity and selectivity, and quantitative, delivering exact thermodynamic and kinetic parameters of interactions. See the difference in this poster! http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/qcm-technology-attana-poster-13272?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/qcm-technology-attana-poster-13272?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document Attana AB Wed, 13 Apr 2011 08:58:00 +0200 Attana has several Quartz Crystal Microbalance (QCM) based instruments and applications, all catering to crucial needs and developed in close collaboration with industry and universities. Examples include kinetic analysis on cell surfaces, candidate selection screening, aggregation characterization, epitope mapping and concentration determination of biopharmaceuticals. http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/attana-biosensor-and-applications-13175?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/attana-biosensor-and-applications-13175?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document Attana AB Wed, 26 Jan 2011 08:53:00 +0100 The journal IPT features an article written by Attana's product manager where he discusses how to achieve biological relevance during research and the benefits of doing so. The article is also available online, see right for link. http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/molecular-interaction-studies-in-cells-exploring-biology-at-a-new-level-11542?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/molecular-interaction-studies-in-cells-exploring-biology-at-a-new-level-11542?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document Attana AB Thu, 11 Nov 2010 09:02:00 +0100 Kinetics on cells using the Attana Cell 200 - two application examples easily explained in Attana's new poster. Select the right candidate early by getting biologically relevant data from interactions directly on the cell surface. http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/kinetics-on-cells-attana-poster-10815?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/kinetics-on-cells-attana-poster-10815?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document Attana AB Wed, 14 Jul 2010 09:07:00 +0200 The objective of this application note was to determine off-rates of antibodies in mouse hybridoma supernatants and scaffold proteins in bacterial lysates using the Attana 200 system and Low Non-specific Binding (LNB) surfaces. Among other things, a method that can be used for clone selection, vaccine screening, biomarker discovery, biomanufacturing and performance studies was developed. http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/attana-application-note-crude-samples-analysis-direct-off-rate-screening-in-supernatants-and-lysates-8618?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/attana-application-note-crude-samples-analysis-direct-off-rate-screening-in-supernatants-and-lysates-8618?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document Attana AB Wed, 30 Jun 2010 09:58:00 +0200 The objective of this application note was primarily to screen mouse IgG antibodies from crude samples for dissociation rates of bound antigen, and to determine detailed kinetic rate constants between the antigen and an antibody selected in the screen. Among other things, a method to capture mouse IgG from hybridoma supernatants was developed which can be replicated for capture of human IgGs. http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/attana-application-note-crude-samples-analysis-screening-and-characterization-of-hybridoma-supernatants-8617?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document http://www.mynewsdesk.com/se/pressroom/attana-ab/document/view/attana-application-note-crude-samples-analysis-screening-and-characterization-of-hybridoma-supernatants-8617?utm_source=rss&utm_medium=rss&utm_campaign=Subscription&utm_content=document Attana AB