2011-12-12 08:50 Aprea STOCKHOLM – December 12, 2011. Aprea AB today announces that the first patient has been dosed in a clinical Phase I/II-study of APR-246. The primary aim of the study is to evaluate safety and pharmacokinetics, but also to make an early assessment of effectiveness. Aprea is a Karolinska Development AB portfolio company. Other main owners are Industrifonden, Östersjöstiftelsen and Praktikerinvest.