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More than 80 percent of all drug candidates in the pharma R&D suffer from poor solubility and are therefore rejected early in the drug discovery process. Now Uppsala University researchers show that the new material Upsalite®, has great potential for development of new formulations of these rejected drugs.
In a new study published today in the journal Plos One, researchers at Uppsala University show that the harmful effect of smoking is aggravated if the person has high blood levels of PCB. This indicates that environmental contaminants interact with other risk factors for various diseases – a field the researchers claim is under-researched.
Get set for 3-4 June: Uppsala University and seven other Swedish actors, has invited politicians, opinion-makers and experts from healthcare, academia and companies to an unconditional and open dialogue on the ways forward in an ageing society. The goal of the Uppsala Health Summit is to move from knowledge to action.
The energy issue, specifically trade in natural gas, has affected the conflict and developments in Ukraine and Russia more than is generally known. This is the view of Stefan Hedlund, a researcher at the Centre for Russian and Eurasian Studies, Uppsala University, Sweden, who has just published a book that addresses the very core of this highly topical subject.
It’s not only the biology of lakes that varies with the climate and other environmental factors, it’s also their chemistry. More knowledge about this is needed to understand the ecology of lakes and their role in the carbon cycle and the climate. A comprehensive study, led from Uppsala Univeristy, Sweden, is today published in the prestigious journal Nature Communications.
It is generally well known that men have an overall shorter life expectancy compared to women. A recent study, led by Uppsala University researchers, shows a correlation between a loss of the Y chromosome in blood cells and both a shorter life span and higher mortality from cancer in other organs.
125 researchers, policymakers, teachers and educators are invited to join the seminar: ”ESD - Call for Action” on 3 June 2014 at Blåsenhus, Uppsala University to discuss and formulate recommendations to reinforce and strengthen education for sustainable development (ESD) in Sweden and abroad.
Using computer simulations to predict which drug candidates offer the greatest potential has thus far not been very reliable, because both small drug-like molecules and the amino acids of proteins vary so much in their chemistry. Uppsala researchers have now cunningly managed to develop a method that has proven to be precise, reliable and general.
In all living organisms, genes are regulated by proteins called transcription factors. The established model states that a gene is switched off as long as a repressing transcription factor is bound to the DNA. For the first time ever, researchers at Uppsala University, Sweden, have been able to study the process in living cells, showing that it may be more complex than previously thought.
The growing problem of resistance to antibiotics is very costly, both in human lives and in resources. Uppsala University is now to be a leading actor in a gigantic EU-funded project in which academia, the pharmaceutical industry and the biotechnology industry will collaborate to fast-track the development of new antibiotics.
1.Schematic human brain with hippocampus in white. 2.Cross section of hippocampus with pyramidal cells depicted with the major incoming fibres SC (schaffer collaterals, green), TA (temperoammonic pathway, blue), SH (septohippocampal pathway, black) 3.The gatekeeper (red) counteract signaling from TA pathway, thereby allowing local inputs from SC pathway on pyramidal cells to become stronger.
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