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How species genetically adapt to their environment is a central question related to the evolution of biodiversity. In a new study scientists at Uppsala University and their colleagues report that whole genome sequencing of Atlantic and Baltic herring revealed hundreds of loci underlying adaptation to the brackish Baltic Sea or timing of reproduction. The study is published today in eLife.
Atrial fibrillation increases the risk of stroke. Treatment with oral anticoagulation reduces this risk but instead increases the risk of bleeding. Today, a new blood test based tool enabling better and more individualized stroke prevention treatment is presented at a congress in Chicago, and simultaneously published in the top-ranked medical journal The Lancet.
A difference of one hundredth of a percent in fitness is sufficient to select between winners and losers in evolution. For the first time researchers have quantified the tiny selective forces that shape bacterial genomes. The story is published today in the prestigious journal PLoS Genetics.
For the first time, researchers have succeeded in passing an antibody through the blood-brain barrier to act as a tracer for PET imaging of the brain. This resulted in more precise information being obtained than with regular radioactive tracers. The study provides hope for more effective diagnosis of early onset Alzheimer’s disease and improvements in monitoring the effects of medication.
Individuals subjected to chronic low-dose exposure to organochlorine pesticides show and increased risk to obtain a future diagnosis of cognitive impairment. This is shown in a international study now published in Environmental International.
Sometimes so-called synonymous mutations occur in DNA. These do not lead to a change in the protein sequence but which may still have major negative effects on the ability of bacteria to survive. New research from Uppsala University has now shown that an organism can efficiently compensate for the negative effects. These findings have been published in the journal Molecular Biology and Evolution.
The human desire to master light has taken us from controlling fire to building global optical networks. But several questions still remain to be answered. At this year's Celsius-Linné lectures on February 18, top international researchers Professor Eli Yablonovitch and Professor Lene Vestergaard Hau will present pioneering ways to manage and manipulate light for use in countless areas.
A new study shows that a novel imaging-based method for defining appropriateness of breast cancer treatment is as accurate as the current standard-of-care and could reduce the need for invasive tissue sampling. The results suggest that the method might lead to more optimal treatment of individual patients.
Most horses today are treasured for their ability to run, work, or be ridden, but have lost their wild-type camouflage: pale hair with zebra-like dark stripes and markings known as the Dun pattern. Now an international team of scientists has discovered what causes the Dun pattern and why it is lost in most horses.
Experiencing a traumatic event can cause life-long anxiety problems, called posttraumatic stress disorder. Swedish researchers from Uppsala University and Karolinska Institutet now show that people with posttraumatic stress disorder have an imbalance between two neurochemical systems in the brain, serotonin and substance P. The greater the imbalance, the more serious the symptoms patients have.
1.Schematic human brain with hippocampus in white. 2.Cross section of hippocampus with pyramidal cells depicted with the major incoming fibres SC (schaffer collaterals, green), TA (temperoammonic pathway, blue), SH (septohippocampal pathway, black) 3.The gatekeeper (red) counteract signaling from TA pathway, thereby allowing local inputs from SC pathway on pyramidal cells to become stronger.