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Using computer simulations to predict which drug candidates offer the greatest potential has thus far not been very reliable, because both small drug-like molecules and the amino acids of proteins vary so much in their chemistry. Uppsala researchers have now cunningly managed to develop a method that has proven to be precise, reliable and general.
In all living organisms, genes are regulated by proteins called transcription factors. The established model states that a gene is switched off as long as a repressing transcription factor is bound to the DNA. For the first time ever, researchers at Uppsala University, Sweden, have been able to study the process in living cells, showing that it may be more complex than previously thought.
The growing problem of resistance to antibiotics is very costly, both in human lives and in resources. Uppsala University is now to be a leading actor in a gigantic EU-funded project in which academia, the pharmaceutical industry and the biotechnology industry will collaborate to fast-track the development of new antibiotics.
At this year’s Celsius-Linnaeus lectures at Uppsala University on February 13, top international researchers will present new findings about the development of the universe and about human evolution and their significance for our living conditions.
Retrieval of ancient DNA molecules is usually performed with special precautions to prevent DNA from researchers or the environment to get mixed in with the DNA from the fossil. However, many ancient fossils have been lying in museum collection for decades, and are contaminated with present-day human DNA before they enter the DNA-laboratory.
Bone cancer in dogs is affected by a variety of genetic risk factors. Researchers from Uppsala University and the Broad Institute show this in a new study published in Genome Biology.
A research study from Uppsala University, Sweden, is now presenting a model of how bacteria can rapidly adapt to environmental changes through smart regulation of their gene expression. This is important not least for our understanding of resistance to antibiotics.
In order to react effectively to changes in the surroundings, bacteria must be able to quickly turn specific genes on or off. Although the overall mechanisms behind gene regulation have long been known, the fine details have eluded scientists for decades. Researchers at Uppsala University can now provide a picture of how proteins regulate genetic expression at the atomic level.
It has long been known that the characteristics of many plants with wide ranges can vary geographically, depending on differences in climate. But changes in grazing pressure and pollination can also affect the genetic composition of natural plant populations, according to a new study.
An international conference on antiziganism in Europe takes place at Uppsala University on 23–25 October. The purpose of the conference is to contribute to a clearer picture of the phenomenon of antiziganism, both historically and in our own time. The stated ambition is to considerably improve the state of knowledge in an area where systematic research was scarce before the year 2000.
1.Schematic human brain with hippocampus in white. 2.Cross section of hippocampus with pyramidal cells depicted with the major incoming fibres SC (schaffer collaterals, green), TA (temperoammonic pathway, blue), SH (septohippocampal pathway, black) 3.The gatekeeper (red) counteract signaling from TA pathway, thereby allowing local inputs from SC pathway on pyramidal cells to become stronger.
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