Schematic illustration of the evolution of the Big Bird lineage on the Daphne Major island in the Galápagos archipelago. Photos © K. Thalia Grant for G. conirostris and Peter R. Grant for the remainder. Reproduced with permission from K. Thalia Grant, and Princeton University Press, which first published the remaining images in 40 Years of Evolution (P. R. Grant & B. R. Grant, 2014).
Understanding how cells within tumors respond to drugs is a critical issue in anticancer drug development. In an article published in Cell Chemical Biology researchers from Uppsala University report a new approach to study cancer cells’ reactions to treatments and present how it can be used to find new promising drug combinations.
Schematic illustration of the evolution of the ruff ‘supergene’. The evolutionary process started with an inversion about 4 million years ago. The altered orientation of genes is illustrated with three of the about 90 genes in the interval. Additional genetic changes have occurred subsequent to the inversion and these have led to the evolution of the Satellite and Faeder male morphs.
1.Schematic human brain with hippocampus in white. 2.Cross section of hippocampus with pyramidal cells depicted with the major incoming fibres SC (schaffer collaterals, green), TA (temperoammonic pathway, blue), SH (septohippocampal pathway, black) 3.The gatekeeper (red) counteract signaling from TA pathway, thereby allowing local inputs from SC pathway on pyramidal cells to become stronger.