This change also indicated that market demand for protein glycosylation services is increasing rapidly, which will bring a bright future for this service in Creative Proteomics.
Protein glycosylation, as one of the main parts of protein post-translational modification, is a kind of glycoconjugates. It occupies a very important position in the biological field, containing proteins and carbohydrates.
It is necessary for protein glycosylation to form a glycoprotein in order to meet various biological demands. Protein glycosylation, as a kind of protein post-translational modification, occurs in the lumen of the endoplasmic reticulum, and then it is transported to all kinds of cellular locations through the Golgi complex.
The reason why Creative Proteomics allocates so much material resources to develop this service is that it plays a very important role in the following aspects: protein targeting, protection, recognition and receptor function and immune function.
Role in Protein targeting
The synthesized proteins in ribosome need to be transported to different cellular locations, which requires a tag to be displayed on the protein. Thus, it can be transported in specific locations where it is required. Protein glycosylation acts as a tag, through which proteins can be recognized by a particular receptor and then targeted to specific locations.
Role in protection
The newly synthesized proteins are very easy to be degraded by the action of different hydrolytic enzymes. Under this condition, glycan portion of protein glycosylation has glycosidic bonds, which have the resistant ability to hydrolytic enzymes, can act as a shield for the them to prevent their action. And then the synthesized proteins will not be degraded by those enzymes.
Role in recognition and receptor
Protein glycosylation acts as the recognition site, functioning as receptors being located at the cell surface, such as G-protein linked cell surface receptor. Protein portion in this case is embedded into the lipid bilayer membrane and the glycan portion is located outward. Thus, the oligosaccharide portion can recognize as long as a specific type of signal comes in contact with the receptor proteins. And then the signaling cascade will begin.
Role in immune function
There is an oligosaccharide moiety of a certain length at the tip of the variable region of the light. This is also called as an antigen binding site. The oligosaccharide, which is linked to the immunoglobulin in the antigen binding site, plays a significant role in immunological functions.
“Because of these important roles and functions in the biological field, Creative Proteomics allocated so much money and materials to develop this service. What’s more, there are also many other services, such as Protein Phosphorylation, Protein Methylation and so on.” said Joseph Scott, a leader in lab.
As increasing demands in biological market, it is promising for Creative Proteomics to develop its all services in biological field.
Creative Proteomics is the proteomics division of Creative Dynamics Inc, an integrated CRO company that provides a full range of drug development services, including Molecular Biology, Biochemistry, Systems Biology, Organic Chemistry, Genomics, Bioinformatics, Structural Biology, Preclinical and Clinical studies.