Crohn’s disease is a chronic inflammatory bowel syndrome that causes inflammation in the gastrointestinal tract. Inflammation can take place anywhere between mouth to anus. It commonly affects end of small intestine (Ileum) and beginning of the colon. Common symptoms of Crohn’s disease from mild to severe intensity include abdominal pain, frequent diarrhea, reduced appetite, and fever. Sometimes rectal bleeding is also observed due to fissures from inflammation at anal canal. Factors responsible for development of Crohn’s disease include hereditary genes, autoimmune reaction that causes inflammatory condition, and environmental factors such as bacteria and virus. It is observed that smokers are more vulnerable to Crohn’s disease.
Crohn’s disease commonly affects the age group of 15 - 35 years. It is diagnosed with blood test and medical imaging techniques. Management of Crohn’s disease includes lifestyle modification, medications, and surgery.
U.S. and Europe to drive the growth of Crohn’s disease treatment market due to high incidence and prevalence
The U.S. and Europe have high incidence of Crohn’s disease, which is expected to drive the growth of market. According to a study published in the Lancet in October, 2017, around 319 (U.S.) and around 322 (Europe) cases of Crohn’s disease per 1, 00,000 people were reported in the mentioned region. According to the journal of Gastroenterology’s on Inflammatory Bowel Disease (IBD) in 2017, around 1.6 million patient in the U.S were suffering from of IBD, out of which considerable section belongs to Crohn’s disease. Such high incidence of Crohn’s disease in the U.S is attributed to high genetic risk associated with this population. Crohn’s disease treatment market is lucrative, owing to chronic nature of disease that require long term therapy with up to 70% chances of relapse.
However, high cost associated with Crohn’s disease is a hindering the growth of market. Also, off patenting of biologic is restraining the growth of the market. Cadila healthcare launched biosimilar of Adalimumab in the U.S. market in 2014 at one fifth of cost of original brand Humira.
Crohn’s Disease Treatment Market Taxonomy
On the basis of drug class:
- Amino salicylates
- Biological agents
On the basis distribution channel:
- Retail Pharmacy
- Hospital Pharmacy
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According to a study published in Karger journal in November 2017, Asia Pacific economies such as India and China have high incidence and prevalence of Crohn’s disease due to factors such as diet, hygiene, and autoimmune response (Increased westernized living). China has high incidence of inflammatory bowel disease with 344 patients per 1, 00,000 population according to epidemiological study published in 2013 in the Gastroenterology Journal. . First line therapy such as amino salicylate and corticosteroids are preferred choice in this region and expected to fuel market here due to low cost associated with these therapies. However, unmet requirements of patient for treatment of Crohn’s disease is restraining the growth of market in this region. For instance, many patients are non-respondent to immunomodulaters, corticosteroids therapy who can be further shifted to biologic product to treat Crohn’s disease, so this market may provide lucrative opportunity for growth. Major pharmaceutical companies are investing in research and development activities to develop novel molecule for treatment of Crohn’s disease. In 2016, Janessan got FDA approval for new biologic drug Ustekinumab (Stelara) to treat Crohn’s disease. Introduction of biosimilar to targets tumor necrosis factor-alpha such as Infliximab, adalimumab, Certolizumab are fueling the growth of Crohn’s disease treatment market. Merck & Co. Inc. recently launched biosimilar version of Janessan’s Remicade (Infliximab) named Reneflexis Pfizer in December 2017, which got FDA approval for biosimilar version of Remicade called Ixifi. These products are expected to boost the growth of Crohns’ disease treatment market.
Key players operating in global Crohn’s disease treatment market include AbbVie Inc., Janssen Biotech, Allergan Inc., Bayer AG, Bristol-Myers Squibb, Pfizer Inc., Boehringer Ingelheim GmbH, F. Hoffmann-La Roche, Eli Lilly and Company, GlaxoSmithKline plc, Novartis International AG, Sanofi, and Takeda Pharmaceutical Company Limited.
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