"The Report Frontier Pharma: Ophthalmology Therapeutics - Gene Therapies and First-in-Class Targets Offer Novel Treatments for Substantial Unmet Needs in a Pipeline Dominated by Angiogenic and Immune Signaling Drugs provides information on pricing, market analysis, shares, forecast, and company profiles for key industry participants. - MarketResearchReports.biz"
The ophthalmologic therapy area encompasses a wide range of disorders affecting the eye and its supporting structures. These include glaucoma, age-related macular degeneration (AMD), diabetic retinopathy (DR), diabetic macular edema (DME) and dry eye syndrome (DES). The therapy area is characterized by vast unmet need, as patients have few treatment options and poor outcomes.
- There are 194 first-in-class products in the ophthalmologic disorder pipeline. Which of these possess the greatest potential to improve disease outcome and be commercially successful, based on their target?
- Analysis of strategic consolidations and deals revealed a high level of activity in recent years for licensing agreements, but a low level of co-development. How do deal frequency and value compare between molecular targets and molecule types, and which first-in-class targets have not yet been involved in deals?
- Visualize the composition of the ophthalmological disorders market in terms of dominant molecule types and targets, and understand the current unmet needs and how they can be addressed. This knowledge allows a competitive understanding of gaps in the market.
- Analyze the ophthalmological disorders pipeline and stratify by stage of development, molecule type and molecular target. There are strong signs in the pipeline that the industry is seeking novel approaches to treating ophthalmological disorders to overcome the overwhelming level of unmet need.
- Assess the therapeutic potential of first-in-class targets. Using a proprietary matrix, first-in-class products have been assessed and ranked according to clinical potential. Promising early-stage targets have been reviewed in greater detail.
- Identify commercial opportunities in the ophthalmological disorders deals landscape by analyzing trends in licensing and co-development deals, and a curated list of ophthalmological disorder therapies that have not yet been involved in deals, and may offer potential investment opportunities.
1 Table of Contents 2
1.1 List of Tables 3
1.2 List of Figures 3
2 Executive Summary 5
2.1 Market Landscape Poised for Entry of Novel Products 5
2.2 Moderately Sized but Strong First-in-Class Pipeline 5
2.3 Strong Uptake of First-in-Class Products in Strategic Consolidations 5
3 The Case for Innovation 6
3.1 Growing Opportunities for Biologic Products 7
3.2 Diversification of Molecular Targets 7
3.3 Innovative First-in-Class Product Development Remains Attractive 7
3.4 Regulatory and Reimbursement Policy Shifts Favor First-in-Class Product Innovation 8
3.5 Sustained Innovation 8
3.6 GBI Research Report Guidance 9
4 Clinical and Commercial Landscape 10
4.1 Therapy Area Overview 10
4.1.1 Glaucoma 10
4.1.2 Age-related Macular Degeneration 10
4.1.3 Diabetic Macular Edema 10
4.1.4 Diabetic Retinopathy 10
4.1.5 Dry Eye Syndrome 11
4.1.6 Inherited Genetic Disorders 11
4.2 Disease Symptoms 11
4.3 Epidemiology and Etiology 12
4.3.1 Glaucoma 13
4.3.2 Age-Related Macular Degeneration 13
4.3.3 Diabetic Retinopathy and Diabetic Macular Edema 13
4.3.4 Dry Eye Syndrome 13
4.4 Diagnosis 13
4.5 Pathophysiology 14
4.5.1 Healthy Eye Physiology 14
4.5.2 Glaucoma 15
4.5.3 Age-Related Macular Degeneration 16
4.5.4 Diabetic Macular Edema and Diabetic Retinopathy 17
4.5.5 Dry Eye Syndrome 17
4.5.6 Inherited Genetic Diseases 18
4.6 Prognosis 18
4.6.1 Glaucoma 18
4.6.2 Age-Related Macular Degeneration 19
4.6.3 Diabetic Retinopathy and Diabetic Macular Edema 19
4.6.4 Dry Eye Syndrome 19
4.7 Treatment Options 20
4.8 Overview of Marketed Products in Ophthalmology 22
4.8.1 Molecule Type and Target Analysis 22
5 Assessment of Pipeline Product Innovation 23