Healthcare Market Desk

Glioblastoma Multiforme (GBM) Treatment Market Share, Company Analysis and Forecast 2019-2026

Press release   •   Sep 17, 2019 10:46 EDT

Glioblastoma multiforme (GBM) is the most frequent and lethal primary brain tumor in adults. The current treatment modalities available in the market are surgical resection followed by chemotherapy and radiotherapy, that unable to increase the overall survival of patient. The main reason behind inability of these treatments are frequent recurrence, invasiveness of GBM and resistance of glioma stem cells to conventional treatments. Therefore, novel alternative treatment strategies are desperately needed and pipeline of GBM already involves a mix of biological, immunotherapy, small molecules and other types of therapeutics. Recent advancements in molecular biology and gene technology have provided attractive novel treatment possibilities for the patients diagnosed with GBM.

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This research report on the glioblastoma treatment market explains various advancements in this market and analyzes the global glioblastoma treatment market based on drugs (commercially available and pipeline) and geographic regions. The report comprises an elaborate executive summary, which includes a market snapshot that provides market dynamics of various segments and sub-segments dominating the market and expected to grow at the highest growth rate during the forecast period are included in the report in a precise manner.

A detailed qualitative analysis of the factors responsible for driving and restraining the growth of the global glioblastoma treatment market and future opportunities has been provided in the market overview section. This section of the report also provides market attractiveness analysis and Porter’s Five Forces analysis and key players’ market share analysis in 2018 in the glioblastoma treatment market. The research report also provides event impact analysis and various drug delivery methods such as nucleic acid delivery method and biomedical delivery method for the treatment of glioblastoma.

Based on drugs, the global glioblastoma treatment market has been segmented into Bevacizumab (Avastin), Temozolomide (Temodar and Temodal and Temcad) and Carmustine (BiCNU). The market for these drugs has been extensively analyzed based on consistency, effectiveness, and sales revenue of the drugs developed by the manufacturers. The market size and forecast in terms of USD million for each drug has been provided for the period from 2016 to 2026. The report on glioblastoma market also provides % compound annual growth rate (CAGR) for each of the market segments mentioned above for the forecast period from 2019 to 2026, considering 2018 as the base year.

Based on pipeline review, the global glioblastoma treatment market has been segmented into late stage (phase III) and early stage (Phase I&II). Drugs available in phase I and II are shown in a tabular format (significance, indication and intervention etc.). Likewise, the market size and forecast in terms of USD million for phase III candidate has been forecasted from 2019 to 2026. The report on the glioblastoma treatment market also provides % compound annual growth rate (CAGR) for each of the phase III molecules individually for the forecast period from 2019 to 2026.

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Geographically, the glioblastoma treatment market has been categorized into North America, Europe, Asia-Pacific and Rest of the World. The market size and forecast for each of these regions have been provided for the period from 2016 to 2026 along with CAGR (%) for the forecast period from 2019 to 2026.

A list of recommendations has been provided for new entrants to help establish a strong presence and for existing market players to increase their market shares. The report concludes with the profiles of major players in the glioblastoma treatment market based on various attributes such as company overview, financial overview, business strategies, product portfolio and recent developments. Major players profiled in this report include AbbVie, Inc., Activartis Biotech GmbH, Bristol-Myers Squibb Co., Merrimack Pharmaceuticals, Inc., F. Hoffman La Roche, and Tau Therapeutics.

The pipeline review of glioblastoma treatment market has been segmented as below:

  • Global Glioblastoma Treatment Market Revenue and Forecast, by Drugs
    • Bevacizumab (Avastin)
    • Temozolomide (Temodar and Temodal and Temcad)
    • Carmustine (BiCNU)
  • Global Glioblastoma Treatment Market Revenue and Forecast, by Geography
    • North America
    • Europe
    • Asia Pacific
    • Rest of the World
  • Global Pipeline Review of Glioblastoma Treatment
    • Overview
    • Late Stage (Phase III)
      • DCVax
      • Rindopepimut (CDX-110)
      • Others
  • Early Stage (Phase I, II and Pre clinical)
    • ABT-414
    • MM-398
    • ARC-100
    • AV0113
    • Cotara
    • Crenolanib
    • SGT-53
    • Endostatin
    • ANG1005
  • Others

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Chapter 1 Preface
1.1 Report Description

Chapter 2 Executive Summary
2.1 Market Snapshot: Global Glioblastoma Multiforme Treatment Market (2014 and 2026)
2.2 Global Glioblastoma Multiforme Treatment Market, by Drug, 2016 (USD Million)
2.3 Comparative Analysis: Glioblastoma Multiforme Treatment Market, by Geography, 2016 and 2026 (Value %)

Chapter 3 Market Overview
3.1 Introduction and Market Definition
3.2 Disease Overview
3.2.1 Subtypes of Glioblastoma Multiforme
3.2.1.1 Signatures and Clinical features of GBM subtypes
3.2.2 Epidemiology
3.2.3 Standard treatment options and alternative therapeutics approaches
3.3 Nucleic Acid Delivery Methods
3.3.1 Virus-based
3.3.2 Nonviral-based
3.3.3 Stem cells
3.4 In Vivo Identification of GBM for Diagnostic Implication
3.4.1 Magnetic Resonance Imaging (MRI)
3.4.2 Computed Tomography (CT)
3.4.3 Positron Emission Tomography (PET)
3.4.4 Others
3.5 Biomolecule delivery systems
3.5.1 For Glioblastoma
3.5.1.1 Example of homing targets, polymeric coatings, nanoparticle configurations, and therapeutic agents utilized in nanoparticle drug delivery for glioma
3.5.2 For other Central Nervous System (CNS) disorders
3.6 Market Dynamics
3.6.1 Drivers
3.6.1.1 Rising geriatric population will drive the GBM treatment market as they are more prone to cause GBM
3.6.1.2 Global Rate of Aging Population
3.6.1.3 Various government and non-government organizations are creating worldwide awareness against GBM
3.6.1.4 The future of glioblastoma treatment market expects introduction of several novel therapies due to its strong pipeline
3.6.2 Restraints
3.6.2.1 GBM is highly resistant to DNA modifying agents hence available therapies have limitations
3.6.2.2 The overall survival period delivered by current FDA approved treatments is less
3.6.3 Opportunities
3.6.3.1 Development of immunotherapy and biological therapy treatments along with novel drug delivery systems add advantage over the current conventional treatments
3.7 Event Impact Analysis
3.8 Global Glioblastoma Treatment Market Revenue and Forecast, by Drugs, 2015 – 2026 (USD Million)
3.8.1 Global Glioblastoma Treatment Market Revenue and Forecast, by Drugs, 2015 – 2026 (USD Million)
3.8.2 Bevacizumab (Avastin)
3.8.2.1 Global Bevacizumab Market Revenue, 2015 - 2026 (USD Million)
3.8.3 Temozolomide
3.8.3.1 Global Temozolomide Market Revenue, 2015 - 2026 (USD Million)
3.8.4 Carmustine (BiCNU)
3.8.4.1 Global Carmustine (BiCNU) Market Revenue, 2015 - 2026 (USD Million)
3.9 Global Glioblastoma Treatment Market Revenue and Forecast, by Geography, 2015 – 2026 (USD Million)
3.9.1 North America
3.9.1.1 North America Glioblastoma Treatment Market Revenue, 2015 - 2026 (USD Million)
3.9.2 Europe
3.9.2.1 Europe Glioblastoma Treatment Market Revenue, 2015 - 2026 (USD Million)
3.9.3 Asia Pacific
3.9.3.1 Asia Pacific Glioblastoma Treatment Market Revenue, 2015 - 2026 (USD Million)
3.9.4 Rest of the World (RoW)
3.9.4.1 Rest of the World Glioblastoma Treatment Market Revenue, 2015 - 2026 (USD Million)
3.10 Competitive Landscape
3.10.1 Global Glioblastoma Treatment Market: Market Share, by Key Players 2016 (%)

Chapter 4 Global Pipeline Review of Glioblastoma Treatment
4.1 Overview
4.2 Pipeline Analysis : Types of Therapies
4.2.1 Targeted Therapy
4.2.1.1 TRC-105
4.2.2 Gene Therapy
4.2.2.1 VB-111
4.2.2.2 TOCA 511
4.2.3 Immunotherapy
4.2.3.1 DCVax-Brain
4.2.3.2 Rindopepimut (CDX-110)
4.2.3.3 Phase II (ACT II, ACT III and ACTIVATE) trial results of Rindopepimut
4.2.3.4 ICT-107
4.2.3.5 Trivax (AV00113)
4.3 Phase I and II Drug Entities

Chapter 5 Recommendations
5.1 Market Strategy for Success
5.1.1 Focus on the development of immunotherapy and biological therapy treatments
5.1.2 Development of novel drug delivery system (NDDS)
5.1.3 Expected intense competition in the near future

Chapter 6 Company Profiles
6.1 AbbVie, Inc.
6.1.1 Company Overview
6.1.2 Financial Overview
6.1.3 Product Portfolio
6.1.4 Business Strategies
6.1.4.1 Acquisitions and partnership for market penetration
6.1.5 Recent Developments
6.2 Activartis GmbH
6.2.1 Company Overview
6.2.2 Financial Overview
Being a privately owned company, the financial results of Activartis Biotech GmbH is not available in the public domain.
6.2.3 Product Portfolio
6.2.4 Business Strategies
6.2.4.1 Strong focus on research and development
6.2.5 Recent Developments
6.3 Agenus Inc.
6.3.1 Company Overview
6.3.2 Financial Overview
6.3.3 Product Portfolio
6.3.4 Business Strategies
6.3.4.1 Acquisition & Merger
6.3.5 Recent Developments
6.4 Arog Pharmaceuticals, Inc.
6.4.1 Company Overview
6.4.2 Financial Overview
6.4.3 Product Portfolio
6.4.4 Business Strategies
6.4.4.1 Research and development
6.4.5 Acquisition of worldwide rights
6.4.6 Recent Developments
6.5 Bristol-Myers Squibb Company
6.5.1 Company Overview
6.5.2 Financial Overview
6.5.3 Product Portfolio
6.5.4 Business Strategies
6.5.4.1 Acquisitions for company’s growth
6.5.5 Recent Developments
6.6 Cavion LLC
6.6.1 Company Overview
6.6.2 Financial Overview
6.6.3 Product Portfolio
6.6.4 Business Strategies
6.6.4.1 New Drug Development
6.7 Celldex Therapeutics Inc.
6.7.1 Company Overview
6.7.2 Financial Overview
6.7.3 Product Portfolio
6.7.4 Business Strategies
6.7.4.1 Strong Pipeline portfolio
6.7.5 Recent Developments
6.8 CTI BioPharma Corporation (Formerly Cell Therapeutics Inc.)
6.8.1 Company Overview
6.8.2 Financial Overview
6.8.3 Product Portfolio
6.8.4 Business Strategies
6.8.4.1 Strong Pipeline portfolio
6.8.5 Recent Developments
6.9 Cortice Biosciences Inc.
6.9.1 Company Overview
6.9.2 Financial Overview
6.9.3 Product Portfolio
6.9.4 Business Strategies
6.9.4.1 Acquisition of Exclusive Commercial Rights
6.9.5 Recent Developments
6.10 Eisai Co., Ltd.
6.10.1 Company Overview
6.10.2 Financial Overview
6.10.3 Product Portfolio
6.10.4 Business Strategies
6.10.4.1 Joint Research Agreement
6.10.4.2 Introduction of new lifestyle information website for breast cancer patients
6.10.5 Recent Developments
6.11 Exelixis Inc.
6.11.1 Company Overview
6.11.2 Financial Overview
6.11.3 Product Portfolio
6.11.4 Business Strategies
6.11.4.1 Strong Pipeline portfolio
6.11.4.2 Partnered compounds
6.11.5 Recent Developments
6.12 F. Hoffmann-La Roche Ltd.
6.12.1 Company Overview
6.12.2 Financial Overview
6.12.3 Product Portfolio
6.12.4 Business Strategies
6.12.4.1 Investment in research and development (R&D)
6.12.4.2 Strengthening core business
6.12.4.3 Mergers and Acquisitions
6.12.5 Recent Developments
6.13 Peregrine Pharmaceuticals, Inc.
6.13.1 Company Overview
6.13.2 Financial Overview
6.13.3 Product Portfolio
6.13.4 Business Strategies
6.13.4.1 Licensing agreements and collaborations
6.13.4.2 Research and development approach
6.13.5 Recent Developments
6.14 OncoSynergy
6.14.1 Company Overview
6.14.2 Financial Overview
6.14.3 Product Portfolio
6.14.4 Business Strategies
6.14.5 Recent Developments
6.15 Merrimack Pharmaceuticals, Inc.
6.15.1 Company Overview
6.15.2 Financial Overview
6.15.3 Product Portfolio
6.15.4 Business Strategies
6.15.4.1 Acquisition and collaboration agreement to gain market share
6.15.5 Recent Developments

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