Bone morphogenetic proteins (BMP) are naturally occurring proteins found in the human body. Identified in 1965 by Marshall Urist, bone morphogenetic proteins are among the most potent growth factors that induce mesenchymal stem cells to differentiate into osteoblast cells. Twenty different types of BMPs have been discovered to date; only BMP 2, 7 and 9 have osteoinductive property and have been proven to play a significant role in bone formation. However, of these, only BMP-2 and BMP-7 are commercially available. These proteins trigger intracellular signal pathways by binding to the receptor of the mesenchymal stem cells resulting in transformation of stem cells into tissue specific progenitor cells. These cells are involved in the synthesis of musculoskeletal tissue formation, extracellular growth and matrix.
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According to the report, the key driver of the global bone morphogenetic protein market is the growing number of physical trauma cases. There has recently been a growth in the number of sports-related injuries as well, further contributing to the growth of this market.
Another major driver of the global bone morphogenetic protein market is the growing percentage of the elderly in the global population. This rising demographic is the most prone to bone complications and is therefore a prime creator of demand for most bone-related healthcare and medical device markets, including the global bone morphogenetic protein market.
However, the global bone morphogenetic protein market is currently seriously hampered by the side effects associated with the off-label usage of market products. Another restraint on the market is the high cost of bone morphogenetic proteins, which is coupled with the overall low rate of approvals with limited indications. Another older restraint on this market is the easy availability of substitutes for bone grafts.
The growth rate can be improved by a faster proliferation of the global bone morphogenetic protein market into the developing economies. In this context, while North America has led the market in 2013, the current focus is being put on the Asia Pacific region by many global players. A high population density coupled with a rapidly evolving healthcare infrastructure is creating a higher appeal for this region. The report expects North America to continue dominating the global bone morphogenetic protein market in the given forecast period, owing to a high number of patients between 40 and 80 years who are suffering from lower back pains.
The report segments the global bone morphogenetic protein market on the basis of types and applications. Based on type, this market has been segmented into rhBMP-2 and rhBMP-7. Of these, the U.S. FDA has approved the use of rhBMP-2 in tibial shaft fractures, opening up its scope of growth more than the latter. rhBMP-7 is mostly used as an alternative in very specific autograft cases.
Based on application, the global bone morphogenetic protein market was dominated by the spinal fusion surgeries segment in 2013, when it held 76.5% of the market.
The key players in the global bone morphogenetic protein market, as detailed in the report, include Cellumed Co. Ltd., Medtronic, and Stryker Corporation.
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