Jul 14, 2011 09:29 EDT Wiklander et al: A series of streptavidin-mimicking molecularly imprinted polymers has been developed and evaluated for their biotin binding characteristics. A combination of radioligand binding studies and surface area analyses demonstrated the presence of selectivity in polymers prepared using methacrylic acid as the functional monomer. See link for full abstract! -->

Jul 06, 2011 09:25 EDT Dahlbäck et al: During pregnancy, the interaction between malaria infected erythrocytes and the placental receptor is mediated by the parasite expressed protein VAR2CSA. A vaccine against placental malaria should induce antibodies inhibiting the interaction between VAR2CSA and CSA. In this study, we used a biosensor technology to examine binding properties... See link for full article! -->

Jun 06, 2011 09:53 EDT Lonza: This poster shows how the Lonza Biologics AggreSolve platform has been expanded and successfully applied to engineer humanized antibodies with good developability profiles; such antibodies have good stability, productivity and retain activity of therapeutic levels, eliminating the need for further, potentially destabilizing, affinity maturation.

May 30, 2011 10:29 EDT University of Stuttgart, Institute of Cell Biology and Immunology: A humanized IgG1 version (ATROSAB) of a murine TNFR1-selective antagonistic antibody (H398) has been generated. The ATROSAB shows identical binding characteristics and sub-nanomolar affinity to both human and rhesus TNFR1.

May 27, 2011 03:26 EDT Attana and Layerlab: Lipoparticles containing a CXCR4 chemokine receptor were immobilized using memLAYER on the Attana LNB Carboxyl chip. The applicability of lipoparticles and memLAYER for functional studies of GPCRs on the Attana A200 biosensor are demonstrated as well as the benefits of the memLAYER-immobilization.

Jun 01, 2011 03:20 EDT To facilitate the study of carbohydrate-protein interactions a method for label-free measurements has been developed using the Attana 100 biosensor to monitor binding events in real time. The method relies on measurement of the inhibition of a well-known carbohydrate-lectin binding pair, Concanavalin A - Yeast mannan, by lectin binding carbohydrates.

Jan 26, 2011 09:55 EST The journal IPT features an article written by Attana's product manager where he discusses how to achieve biological relevance during research and the benefits of doing so. The article is also available online, see right for link.

Nov 10, 2010 10:39 EST Kinetics on cells using the Attana Cell 200 biosensor - two application examples easily explained in Attana's new poster. Select the right candidate early by getting biologically relevant data from interactions directly on the cell surface.

Jun 04, 2010 09:16 EDT A list of publications where the Attana systems have been utilized. The publications relate to various species such as glycovesicles, antibodies, proteins, nanobodies and more.

Jun 16, 2010 10:40 EDT The objective of this application note was to evaluate newly developed therapeutic antibodies in a biologically relevant context (cells) in order to detect failing candidates at an earlier stage. Among other things, it was found that real-time screening of drug candidates in a synthetic and in a cellular context together provides highly informative and biologically relevant data.

Jun 23, 2010 10:54 EDT The objective of this application note was to determine the binding properties of the lectin ConA towards human epidermoid carcinoma cells. Among other things it was found that a kinetic approach may be used to determine the apparent affinity and rate constants of lectin-cell glycan interactions, providing a greater understanding of the mechanism involved in the lectin recognition of cancer cells.

Jul 14, 2010 10:19 EDT The objective of this application note was to determine off-rates of antibodies in mouse hybridoma supernatants and scaffold proteins in bacterial lysates using the Attana 200 system and Low Non-specific Binding (LNB) surfaces. Among other things, a method that can be used for clone selection, vaccine screening, biomarker discovery, biomanufacturing and performance studies was developed.