Clarification of the Interactions between Lipoproteins and Chondroitin-6-sulfate

Apr 04, 2012 10:28 EDT Attana AB Three different experimental approaches were used for obtaining a comprehensive view and understanding of the interactions between apolipoprotein B-100 (ApoB-100) of low-density lipoprotein and apolipoprotein E (ApoE) of high-density lipoprotein and chondroitin-6-sulfate (C6S) of arterial proteoglycan. Read the full abstract here:

Photogenerated lectin sensors produced by thiol-ene/yne photo-click chemistry in aqueous solution

Mar 28, 2012 10:22 EDT Attana AB The photoinitiated radical reactions between thiols and alkenes/alkynes (thiol-ene and thiol-yne chemistry) have been applied to a functionalization methodology to produce carbohydrate-presenting surfaces for analyses of biomolecular interactions. Read the full abstract here:

Real-time analysis of  carbohydrates on cell surfaces using a QCM biosensor-a lectin-based approach

Mar 20, 2012 11:10 EDT Attana AB The real-time lectin screening of a range of lectins, including ConA, DBA, PNA and UEA-I, enabled the accurate study of the glycosylation changes between cells, such as changes associated with cancer progression and development. Furthermore, the kinetic parameters of the interaction of Con A with MDA-MB-468 cells were studied. Read the full abstract here:

Treatment of solid tumors with single-walled carbon nanotubes

Mar 06, 2012 09:05 EST Attana AB Single-walled carbon have properties that make them useful for drug delivery, and their photo-thermal effects make them potentially useful in a wide range of applications, particularly the treatment of solid tumors. Follow link for full abstract: See abstract on video (Attana Cell 200 data shown in min 04:55)

Halo Genomics in Dagens Nyheter, article by Juan Flores

Nov 09, 2011 12:13 EST Halo Genomics

Olink utser ny verkställande direktör och utökar styrelsen

Sep 14, 2011 10:07 EDT Olink Bioscience UPPSALA 14 september 2011 – Simon Fredriksson, vice verkställande direktör och vetenskaplig chef på Olink AB (Olink) har idag utsetts till verkställande direktör i bolaget. Simon Fredriksson tar över efter Björn Ekström som har lett företaget sedan starten 2004. Samtidigt har ett antal nya medlemmar invalts i Olinks styrelse.

Towards a Synthetic Avidin Mimic

Jul 14, 2011 09:29 EDT Attana AB Wiklander et al: A series of streptavidin-mimicking molecularly imprinted polymers has been developed and evaluated for their biotin binding characteristics. A combination of radioligand binding studies and surface area analyses demonstrated the presence of selectivity in polymers prepared using methacrylic acid as the functional monomer. See link for full abstract! -->

MIP Thin Films on Quartz Crystal Microbalance

Jul 11, 2011 09:54 EDT Attana AB Lund University: Molecularly imprinted polymers (MIPs) were prepared in situ on Attana's quartz crystal sensor surface with good reproducibility and long-term stability. The resulting MIP surfaces can be used for detection and discrimination between very similar molecules, and the analysis is fast enough to allow for large amounts of samples.

The Chondroitin Sulfate A-binding Site of the VAR2CSA Protein Involves Multiple N-terminal Domains

Jul 06, 2011 09:25 EDT Attana AB Dahlbäck et al: During pregnancy, the interaction between malaria infected erythrocytes and the placental receptor is mediated by the parasite expressed protein VAR2CSA. A vaccine against placental malaria should induce antibodies inhibiting the interaction between VAR2CSA and CSA. In this study, we used a biosensor technology to examine binding properties... See link for full article! -->

Improving the Developability of Biopharmaceuticals

Jun 28, 2011 11:07 EDT Attana AB Attana and Lonza in collaboration: The combination of computational and protein engineering tools with novel orthogonal methods of measuring aggregation can be used to assess the developability of biopharm products in the early stages of development, thereby reducing the level of risk in later stages.