Temperature optimum

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Temperature optimum

View of the part of the enzyme that controls the temperature optimum. The loop region that is shown in dark blue is from the Antarctic bacterium and that shown in red from the pig enzyme. By introducing mutations into the Antarctic structure the loop could be moved towards the pig structure and the temperature optimum raised.
Johan Åqvist
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Johan Åqvist
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  • View of the part of the enzyme that controls the temperature optimum. The loop region that is shown in dark blue is from the Antarctic bacterium and that shown in red from the pig enzyme.

    Scientists designed new enzyme using Antarctic bacteria and computer calculations

    For the first time, researchers have succeeded in predicting how to change the optimum temperature of an enzyme using large computer calculations. A cold-adapted enzyme from an Antarctic bacterium was used as a basis. The study is to be published in the journal Science Advances and is a collaboration between researchers at Uppsala University and the University of Tromsø.

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