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Probiotics may provide relief for infants with colic, new study reveals

Press release   •   Dec 04, 2019 10:01 UTC

Up to one in four infants globally suffer from excessive crying and fussing – often called colic. A new study shows that the BB-12®1 probiotic strain may help reduce crying duration and the number of crying episodes and bring relief to infants and their parents

The results from a new clinical trial show that the daily intake of probiotic strain Bifidobacterium (BB-12®) may provide help to infants suffering from colic around the world. 80% of the infants supplemented with Bifidobacterium (BB-12®) met the trial primary endpoint criteria, showing a reduction in duration of crying by 50% or more.

“As a father of four, I know all too well the impact on the whole family of a crying baby that just can’t be soothed. That’s why I’m very excited by these results which clearly show that the BB-12® probiotic strain may help manage colic, providing an improved quality of life for the whole family during these first few months of the baby’s life”, explains Andrew Scorey, head of Human Health at Chr. Hansen.

Up to 25% of infants worldwide suffer from colic2
Associated with parental guilt, frustration, sleep problems and visits to the doctor, excessive crying and fussing – often called colic – is a source of major distress for the infants, parents and caregivers. It’s one of the most common reasons parents seek medical advice during the first three months of their baby’s life3. And yet the exact cause for colic is largely unknown.

Colic is defined as severe pain in the abdomen caused by wind or obstruction in the intestines and suffered especially by babies. Characterized by excessive crying, grimacing, a red face, knees drawn up to the chest, clenched fists and excessive gas4, the answer seems to lie in the gut. Babies with colic have lower counts of good bacteria and increased concentrations of undesirable bacteria in their digestive tracts5,6.

“The probiotic strain Bifidobacterium (BB-12®) may ease colic by modifying the microbiota in infants with intestinal dysbiosis. The results indicate that the strain does this by increasing bifidobacterial abundance and by inhibiting the increase of harmful bacteria,” explains senior scientific advisor at Chr. Hansen, Ulla Holmboe Gondolf.

One of the most documented strains in the world
The trial was conducted in Italy by Professor Roberto Berni Canani and has been published in medical journal Alimentary Pharmacology & Therapeutics: “The therapeutic efficacy of Bifidobacterium animalis subsp. lactis (BB-12®) in infant colic: a randomized, double blind, placebo-controlled trial”.

The 80 breast fed infants in the trial were seven weeks or younger and had all been diagnosed with colic according to Rome III criteria. The infants were given a placebo, or 1 billion live bacteria per day of Bifidobacterium (BB-12®) oil drops provided by Chr. Hansen over 28 days.

Bifidobacterium (BB-12®) has been used worldwide since 1985 as an ingredient in food and dietary supplements. It has been described in more than 315 scientific publications where more than 190 of these are from clinical studies7.

References

1 BB-12® is a trademark of Chr. Hansen A/S |2 Wolke et al. J Pediatr. 2017;185:55-61.e4 | 3 Kheir et al. Ital J Pediatr, 2012;38:34| 4 National Health Service 2019; https://www.nhs.uk/conditions/colic/ |5 Zeevenhooven et al. Nat Rev Gastroenterol Hepatol, 2018;15:479-496. | 6 Mayer et al. J Clin Invest, 2015;125:926-38. | 7 As at August 2019.

Chr. Hansen is a leading, global bioscience company that develops natural solutions for the food, nutritional, pharmaceutical and agricultural industries. We develop and produce cultures, enzymes, probiotics and natural colors for a rich variety of foods, confectionery, beverages, dietary supplements, animal feed, and plant protection. Our product innovation is based on around 40,000 microbial strains – we like to refer to them as “good bacteria”. Our solutions enable food manufacturers to produce more with less – while also reducing the use of chemicals and other synthetic additives – which makes our products highly relevant in today’s world. Sustainability is an integral part of Chr. Hansen’s vision to improve food and health. In 2019 Chr. Hansen was ranked as the world’s most sustainable company by Corporate Knights thanks to our strong sustainability efforts and our many collaborative partnerships with our customers. We have been delivering value to our partners – and, ultimately, end consumers worldwide – for over 145 years. We are proud that more than one billion people consume products containing our natural ingredients every day. Chr. Hansen was founded in 1874 and is listed on Nasdaq Copenhagen.


Disclaimer
The statements contained in above press release are not evaluated as Health Claims by authorities. Users should conduct their own legal and suitability investigations to ensure that all national requirements are followed. These statements have not been evaluated by the US Food and Drug Administration. The products are not intended to diagnose, cure or prevent any diseases. Full Chr. Hansen’s full Legal Notice, visit: https://www.chr-hansen.com/en/legal-notice

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