Dealing by Directors - Companies Act 1985 Section 324/329

We hereby inform you that on 23 September 2004, Mr J R Symonds, a Director of AstraZeneca PLC was granted an option under the company's savings related share option plan. The option is exercisable over the company's USD0.25 ordinary shares. Name of Director: J R Symonds Number of additional shares under option: 418 Exercise price per share: 2262P Period when exercisable: 01.12.07-31.05.08 Total number of shares under option: 252,855 G H R Musker Company Secretary 23 September 2004