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MetaboGen and BioGaia initiates program for microbiome restoration
MetaboGen and BioGaia have agreed to initiate a new development program addressing restoration of the microbiome after antibiotic treatment. The program will combine expertise and experience from both companies and is part of the long-term relationship between MetaboGen and BioGaia.
The microbiome has gained considerable interest as modulators of health and disease over the past 15 years. The human gut microbiome consists of 500-1000 species distributed over a few phyla, where most species belong to Firmicutes and Bacteroidetes. An altered microbiome has been associated with several different life-style diseases such as obesity, type 2 diabetes and inflammatory bowel disorder. In general, these diseases are characterized by reduced microbial diversity. Antibiotics are commonly used and can disrupt the microbial ecology.
In a recent study, it was demonstrated that ciprofloxacin had profound and rapid effect on the gut microbiota, with a loss of diversity and a shift in community composition occurring within 3–4 d of drug initiation. By one week after the end of each course, communities began to return to their initial state, but the return was often incomplete. Although broadly similar, community changes after ciprofloxacin varied among subjects and between the two courses within subjects. In all subjects, the composition of the gut microbiota stabilized by the end of the experiment but was altered from its initial state. As with other ecosystems, the human distal gut microbiome at baseline is a dynamic regimen with a stable average state. Antibiotic perturbation may cause a shift to an alternative stable state, the full consequences of which remain unknown. Thus, it may be essential to recover the microbiome after treatment with antibiotics.
For more information, please contact:
Sara Malcus, CEO MetaboGen AB
Email: sara.malcus@metabogen.com
Phone: +46 705-82 32 22
About MetaboGen AB
MetaboGen is a research-driven company with a focus on the microbiome and its impact on health, based in Gothenburg, Sweden. The company was founded based on break through science from the labs of Professor Fredrik Bäckhed (University of Gothenburg) and Professor Jens B Nielsen (Chalmers University of Technology). Since 2011, MetaboGen develops products based on advanced mapping of the intestinal microflora composition. In 2014 BioGaia AB invested in the company. MetaboGens technology along with more than 25 years of experience in the development of probiotics from BioGaia, provides the company with a unique opportunity to develop the next generation of microbial products. MetaboGen has its headquarters and laboratory at the AstraZeneca BioVenture hub, Mölndal, Sweden. For more information see www.metabogen.com
BioGaia is an innovative Swedish health care company and a world leader in probiotics with more than 25 years experience of developing, marketing and selling probiotic products. Over the years we have created global networks of leading, independent researchers and specialists, manufacturing experts and local distribution partners worldwide. BioGaia’s products are sold in around 90 countries. The largest segment is paediatrics, accounting for over 80 per cent of total sales. Our focus is on finished consumer products that are sold under our own BioGaia brand. For more information see www.biogaia.com
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