Why did ocean productivity decline abruptly 4.6 million years ago?
By drilling deep down into sediments on the ocean floor researchers can travel back in time. A research team led from Uppsala University now presents new clues as to when and why a period often referred to as the ‘biogenic bloom’ came to an abrupt end. Changes in the shape of the Earth's orbit around the Sun may have played a part in the dramatic change.
The focus of financial reporting influences business cycles
Editorial choices can impact the amplitude of business cycles even if the information that is reported is correct. On reason is that the focus of the reports can be on sectors that are non-representative of the economy in general. A new study shows that financial reporting can explain up to 20 per cent of the business cycles for GDP and 40 per cent of the business cycles for unemployment.
Zebrafish and AI replace some mouse experiments in cancer research
Researchers at Uppsala University have used AI to develop a new method to study brain cancer. The method is based on transplanting tumour cells from patients to fish embryos, followed by observation with AI. The method, which is described in the scientific journal Neuro-Oncology, can partly replace current mouse models for studying tumour growth and treatment.
Small measures can be a big help for children of mothers with depression
Several new studies among Syrian refugee families in Turkey and families with infants in Sweden and Bhutan show that children of mothers in poor mental health risk falling behind in their cognitive development. However, very small changes can suffice to break this correlation and enable the children to return to their normal developmental level. The solutions where the same in all three countries
Hunt for the protein TGM1 led to disease discovery
Searching for the protein TGM1 among patients with autoimmune skin diseases, researchers have identified a separate disease that can be linked to autoimmunity against TGM1. This backward method demonstrates a new way of identifying autoantigens as markers for serious diseases. By letting autoantigens point to the disease, diagnosis and treatment can be facilitated, shows study published in PNAS.
Several protein biomarkers protect against disease development
A comprehensive study from Uppsala University shows that several disease-associated protein biomarkers protect healthy individuals from developing inflammatory diseases. The protective effects are attributed to the proteins’ function in preventing tissue damage, a function that might be very different from the effect in a tissue subjected to chronic or acute inflammation.
Genes associated with hearing loss visualised in new study
Researchers from Uppsala University have been able to document and visualise hearing loss-associated genes in the human inner ear, in a unique collaboration study between otosurgeons and geneticists. The findings illustrate that discrete subcellular structures in the human organ of hearing, the cochlea, are involved in the variation of risk of age-related hearing loss in the population.
Blocking inhibits SARS-CoV-2 infection of human cells
Researchers have developed and used a new method to map interactions on a large scale between human proteins and coronavirus proteins, which has provided valuable new information. In collaborations with others, they show that blocking one of these interactions inhibited infection of human cells by SARS-CoV-2. They also confirmed the interaction between the viral protein and the human protein.
Spin Mixing in Ferromagnets Revealed
For the first time through experiments and theory, Uppsala researchers, together with international collaborators, have been able to measure spin mixing in a ferromagnetic material. Through the experimental measurements, they discovered that a common factor in spin equations, in common use since the 1950s, has been significantly underestimated.
In addition to the well known electric charge,
Expectations and dopamine can affect outcome of SSRI treatment
Levels of dopamine and placebo effect can determine whether social anxieties improve when treated with SSRIs. The effect was four times higher for patients with high expectations compared with low expectations, even though the groups received the same medical treatment. Although SSRIs influence levels of serotonin in the brain, the effects on dopamine had the greatest impact for improvement.
Why some Darwin’s finch nestlings have yellow beaks
Carotenoids are the underlying pigment for much of the enormous variety in color found across birds and form the basis for the colors red, yellow, and orange. In a study published in Current Biology, researchers from Uppsala University and Princeton University have uncovered the genetic basis for the yellow beak of some Darwin’s finch nestlings.
Pathways to lifelong mental wellbeing in focus at Uppsala Health Summit
Increasing mental ill health is one of the most urgent public health challenges in the world. The global meeting Uppsala Health Summit, to be held online on 18–21 October, will discuss which preventive measures societies should deploy to better address this troubling trend.