When many genes regulate a single trait, they commonly work together in large clusters or ‘networks’. Taking this into account allows better predictions of how an individual’s genetic make-up affects the trait concerned. The risk of perceiving the importance of an individual gene incorrectly is also reduced.
The history of people and landscapes, whether natural or cultural, is fundamentally connected. Answering key historical questions about this relation will allow us to approach our most important environmental issues in novel ways. Today in the open access journal PLOS ONE archeologists present a list of 50 priority issues for historical ecology.
A new study, looking at the sex-specifically inherited X chromosome of prehistoric human remains, shows that hardly any women took part in the extensive migration from the Pontic-Caspian Steppe approximately 5,000 years ago. The great migration that brought farming practices to Europe 4,000 years earlier, on the other hand, consisted of both women and men.
In a collaborative effort, researchers at Uppsala and Umeå University now show that the formation of methylmercury in sediment is controlled by the molecular composition of the organic matter. The study has been published in Nature Communications.
Researchers have now found an explanation for what triggered the largest volcanic eruption witnessed by humankind. The volcano’s secret was revealed by geochemical clues hidden inside volcanic quartz crystals.
Patients with glioblastoma have very poor prognosis since there are no effective therapies. In a study published in Cell Reports, researchers at Uppsala University have discovered a correlation between the cell type from which the tumour originates and the growth and drug sensitivity of the tumour.
In a new study, researchers at Uppsala University have found evidence of that climate change upends selection of face characteristics in the collared flycatcher. During the study the annual fitness selection on forehead patch size switched from positive to negative, a reversal that is accounted for by rising spring temperatures at the breeding site.
In a new study, researchers at Uppsala University have found evidence of a new principle for how epigenetic changes can occur. The principle is based on an enzyme, tryptase, that has epigenetic effects that cause cells to proliferate in an uncontrolled manner.
When clamping of the umbilical cord is delayed, iron deficiency up to six months of age can be prevented, according to a new study from Uppsala University, published in JAMA Pediatrics. The study was conducted in Nepal.
Immunotherapy has proven to be effective against many serious diseases. But to treat diseases in the brain, the antibodies must first get past the obstacle of the blood-brain barrier. In a new study, a research group at Uppsala University describes their development of a new antibody design that increases brain uptake of antibodies almost 100-fold.
It is beneficial to systematise the exchange of information between parents, preschool and child care centres (CHCs) to increase the focus on young children with mental health problems. This is shown in a recently conducted study from Uppsala University, published in the journal PLOS One.
In a study published in the scientific journal Oncotarget, researchers from Uppsala University show how the protein EZH2 affects the development of multiple myeloma, and that inhibition of EZH2 could be used as a new strategy to treat the disease. The tumour form multiple myeloma is today incurable and it has been challenging to improve therapy.