Reference reagents are important in diagnostics and care of patients with systemic lupus erythematosus (SLE). An international team of researchers now presents a WHO autoantibody reference reagent that will help to align autoantibody analyses and thus to optimise diagnosis and treatment to patients irrespective of where they live. The findings are published in Annals of the Rheumatic Diseases.
A new study examines the historical and genetic origins of the White Plymouth Rock chicken, an important contributor to today’s meat chickens (broilers). Researchers at Uppsala University in Sweden, The Livestock Conservancy and Virginia Tech in the USA have used genomics to study breed formation and the roots of modern broilers.
A single amino acid change in the light-sensing rhodopsin protein played a critical role when herring adapted to the red-shifted light environment in the Baltic Sea, shows an study by an international team of scientists, led by researchers from Uppsala University, which is published in PNAS. Remarkably about one third of all fish living in brackish or freshwater carry the same change.
Modern flamingoes employ filter feeding and their feces are, as a result, rich in remains of microscopically-small aquatic prey. Very similar contents are described from more than 150 million year old pterosaur droppings in a recent paper in PeerJ. This represents the first direct evidence of filter-feeding in Late Jurassic pterosaurs.
There is a growing demand for diagnostic markers for early disease detection and prognosis. Exosomes are potential biomarkers for cancer progression and neurodegenerative disease but it can be difficult to identify what tissue a specific exosome comes from. Researchers have solved this problem by developing a method that maps surface protein complements on large numbers of individual exosomes.
The problem of access to safe drinking water in most parts of Bangladesh is a persistent challenge. Now, a team of scientists shows that a locally growing and previously unexploited green macroalgae species could be used to extract cellulose nanofibers, which can then be formed into paper sheets with tailored pore size that are utilized for point-of-use water treatment.
Long-lived mushrooms that grow in ‘fairy rings’ accumulate surprisingly few mutations over time. This finding indicates that their protection against harmful mutations is well developed. The results, to be published in the esteemed journal Current Biology, are interesting in terms of both medicine and evolutionary biology.
In a new study from SciLifeLab at Uppsala University, researchers have found a total of 141 regions (genes) in our genetic material that largely explain the genetic risk underlying asthma, hay fever and eczema. As many as 41 of the genes identified have not previously been linked to an elevated risk for these diseases. The results are published in the scientific journal Human Molecular Genetics.
Soon we will be able to replace fossil fuels with a carbon-neutral product created from solar energy, carbon dioxide and water. Researchers at Uppsala University have successfully produced microorganisms that can efficiently produce the alcohol butanol using carbon dioxide and solar energy, without needing to use solar cells. The results have been published in Energy & Environmental Science.
Bacterial ribosomes need a single-stranded ribosome binding site (RBS) to initiate protein synthesis, whereas stable RNA structure blocks initiation. Paradoxically, structured mRNAs can nevertheless be efficiently translated. Researchers at Uppsala University have now elucidated the anatomy of a "standby" site and its requirements, to overcome RNA structure problems for translation.
The majority of women who undergo surgery for suspected ovarian cancer do not have cancer. A novel blood test developed by researchers at Uppsala University and University of Gothenburg, now offers the possibility of more precise diagnostics. This could lead to a reduction in unnecessary surgery and to earlier detection and treatment for affected women. (Communications Biology).
One key question in evolutionary biology is how novel genes arise and develop. Swedish researchers now show how new genes and functions that are advantageous to bacteria can be selected from random DNA sequences. The results are presented in the scientific journal mBio.