Although many people know what increases the risk of cardiovascular diseases, such as heart attacks, not everyone recognises their own risk factors. This is shown by a new study of 423 Swedes aged 40–70 years, which has now been published in the scientific journal Preventive Medicine Reports.
CRISPR-Cas9, the “genetic scissors”, creates new potential for curing diseases; but treatments must be reliable. In a new study, researchers have discovered that the method can give rise to unforeseen changes in DNA that can be inherited by the next generation. These scientists therefore urge caution and meticulous validation before using CRISPR-Cas9 for medical purposes.
A new study, led by researchers at Uppsala University, shows that all individual patients suffering from severe COVID-19 may have lower oxygen requirements than was formerly believed. The study was conducted at a Swedish district hospital during the first wave of the pandemic in 2020. The scientists’ methods, as well as their results, may be useful for future planning of health care and resources.
In an article in the scientific journal Science, researchers at Uppsala University show how a DNA-binding protein can search the entire genome for its target sequence without getting held up on the way. The result contradicts our current understanding of gene regulation - the genetic code affects how often the proteins bind, but not for how long.
In a new study, participants underwent an intense bout of exercise after both normal sleep and after three nights of curtailed sleep. When they exercised after curtailed sleep, the levels of the heart injury biomarker troponin increased slightly more, compared with when the participants performed exercise in their well-rested condition.
By drilling deep down into sediments on the ocean floor researchers can travel back in time. A research team led from Uppsala University now presents new clues as to when and why a period often referred to as the ‘biogenic bloom’ came to an abrupt end. Changes in the shape of the Earth's orbit around the Sun may have played a part in the dramatic change.
Editorial choices can impact the amplitude of business cycles even if the information that is reported is correct. On reason is that the focus of the reports can be on sectors that are non-representative of the economy in general. A new study shows that financial reporting can explain up to 20 per cent of the business cycles for GDP and 40 per cent of the business cycles for unemployment.
Researchers at Uppsala University have used AI to develop a new method to study brain cancer. The method is based on transplanting tumour cells from patients to fish embryos, followed by observation with AI. The method, which is described in the scientific journal Neuro-Oncology, can partly replace current mouse models for studying tumour growth and treatment.
Several new studies among Syrian refugee families in Turkey and families with infants in Sweden and Bhutan show that children of mothers in poor mental health risk falling behind in their cognitive development. However, very small changes can suffice to break this correlation and enable the children to return to their normal developmental level. The solutions where the same in all three countries
Searching for the protein TGM1 among patients with autoimmune skin diseases, researchers have identified a separate disease that can be linked to autoimmunity against TGM1. This backward method demonstrates a new way of identifying autoantigens as markers for serious diseases. By letting autoantigens point to the disease, diagnosis and treatment can be facilitated, shows study published in PNAS.
A comprehensive study from Uppsala University shows that several disease-associated protein biomarkers protect healthy individuals from developing inflammatory diseases. The protective effects are attributed to the proteins’ function in preventing tissue damage, a function that might be very different from the effect in a tissue subjected to chronic or acute inflammation.
Researchers from Uppsala University have been able to document and visualise hearing loss-associated genes in the human inner ear, in a unique collaboration study between otosurgeons and geneticists. The findings illustrate that discrete subcellular structures in the human organ of hearing, the cochlea, are involved in the variation of risk of age-related hearing loss in the population.