An African man who lived just 350 years ago was buried in a prehistoric shell midden in Amoreira in Portugal, well known by archaeologists for the cemeteries of the last hunter-gatherers living in the area, 8 000 years-ago. To investigate this burial researchers from Uppsala University and Universidade de Lisboa combined biomolecular archaeology, ancient DNA, and historical records.
By linking human population studies with experiments in cell and animal models, researchers have provided evidence that complex mixtures of endocrine disrupting chemicals impact children’s brain development and language acquisition. With their novel approach, the scientists show that up to 54 per cent of pregnant women were exposed to experimentally defined levels of concern.
Researchers at Uppsala University have discovered that the ancestors of legionella bacteria infected eukaryotic cells as early as two billion years ago. It happened soon after eukaryotes began to feed on bacteria. These results, described in a new study published in Molecular Biology and Evolution, also contributes to the chicken-or-egg debate about whether mitochondria or phagocytosis came first
Uppsala researchers have succeeded in designing a molecule that inhibits the replication of coronaviruses and that has great potential for development into a drug suitable for treating COVID-19. The molecule is effective against both the new variant and previously identified coronaviruses. The article has been published in the Journal of the American Chemical Society.
For many years, researchers at Uppsala University have been exploring the genetic origins of the Scandinavian grey wolf population, which was founded by only three immigrating wolves. In their new study the scientists show that, after five generations of inbreeding, between 10 and 25 per cent of the original genetic variation has been eliminated.
Although many people know what increases the risk of cardiovascular diseases, such as heart attacks, not everyone recognises their own risk factors. This is shown by a new study of 423 Swedes aged 40–70 years, which has now been published in the scientific journal Preventive Medicine Reports.
CRISPR-Cas9, the “genetic scissors”, creates new potential for curing diseases; but treatments must be reliable. In a new study, researchers have discovered that the method can give rise to unforeseen changes in DNA that can be inherited by the next generation. These scientists therefore urge caution and meticulous validation before using CRISPR-Cas9 for medical purposes.
A new study, led by researchers at Uppsala University, shows that all individual patients suffering from severe COVID-19 may have lower oxygen requirements than was formerly believed. The study was conducted at a Swedish district hospital during the first wave of the pandemic in 2020. The scientists’ methods, as well as their results, may be useful for future planning of health care and resources.
In an article in the scientific journal Science, researchers at Uppsala University show how a DNA-binding protein can search the entire genome for its target sequence without getting held up on the way. The result contradicts our current understanding of gene regulation - the genetic code affects how often the proteins bind, but not for how long.
In a new study, participants underwent an intense bout of exercise after both normal sleep and after three nights of curtailed sleep. When they exercised after curtailed sleep, the levels of the heart injury biomarker troponin increased slightly more, compared with when the participants performed exercise in their well-rested condition.
By drilling deep down into sediments on the ocean floor researchers can travel back in time. A research team led from Uppsala University now presents new clues as to when and why a period often referred to as the ‘biogenic bloom’ came to an abrupt end. Changes in the shape of the Earth's orbit around the Sun may have played a part in the dramatic change.
Editorial choices can impact the amplitude of business cycles even if the information that is reported is correct. On reason is that the focus of the reports can be on sectors that are non-representative of the economy in general. A new study shows that financial reporting can explain up to 20 per cent of the business cycles for GDP and 40 per cent of the business cycles for unemployment.