Cellular lipids are more efficient than proteins in trapping most drugs and hence reducing the free intracellular drug concentration. This is shown by researchers at Uppsala University in an article published in Molecular Pharmaceutic.
One strategy for cancer therapy is to inhibit the development of blood vessels in the tumour. Researchers at Uppsala University show in a new study how the protein CD93 interacts with the protein network that is required for tumour vessels to form properly. Blocking this interaction could be used as a means to hamper blood vessel development and slow down the cancer.
A new study in the Journal of Child Psychology and Psychiatry suggests that infants who pay little attention to synchronous sights and sounds may be at elevated risk of later being diagnosed with autism spectrum disorder (ASD). This knowledge about early development in ASD may contribute to earlier detection and intervention in the future.
Participation in a post-traumatic stress group can be an effective help for unaccompanied refugee minors. In a new study, one in five young people completely recovered from their symptoms of post-traumatic stress disorder and many reported improved symptoms after having participated in a group. The study from Uppsala University is the first in Scandinavia using the Teaching Recovery Techniques.
What was previously thought to be typical Viking Age, silver patterns on woven silk bands, could in fact be geometric Kufic characters. As part of an exhibition at the Enköping Museum, ongoing research is presented where a textile archaeological analysis suggests that both Allah and Ali are invoked in the pattern of the bands.
Previous research has shown that there is a connection between epigenetic changes and some of our common illnesses. But what does this connection mean? A new study shows that external factors, such as lifestyle aspects, often affect both the epigenetic pattern and cause the disease. The results have been published in PLOS Genetics.
Preschool children in joint physical custody have less psychological symptoms than those who live mostly or only with one parent after a separation. That shows a new Swedish study of 3,656 children, done by researchers from Uppsala University, Karolinska Institutet and the research institute CHESS, which is now published in Acta Pædiatrica.
Newly discovered human-like footprints from Crete may put the established narrative of early human evolution to the test. The footprints are approximately 5.7 million years old and were made at a time when previous research puts our ancestors in Africa – with ape-like feet.
An extensive exercise to map genetic variation in Sweden has found 33 million genetic variants, 10 million of which are novel. Large-scale DNA sequencing methods were used to analyse the whole genome of 1000 individuals from different parts of the country. The study was led by researchers at Uppsala University, who have published their findings in the European Journal of Human Genetics.
"Which factors increase the chance of aging with well-maintained functions?" Older men who never smoked, avoided obesity and had held a healthy Mediterranean-inspired diet have good chances of maintaining their independence at a very high age.
By blocking of an enzyme that affects the cellular microenvironment it is possible to stop brain tumour cells from growing. This is shown in a new study published in the journal Molecular Cancer Therapeutics by researchers at Uppsala University in collaboration with researchers in Haifa, Israel and Brisbane, Australia.
In the latest issue of the journal Proceedings of the National Academy of Sciences (PNAS), a research group at Uppsala University presents a new, small-scale method that may become a smart shortcut for determining the “bioavailability” of a pharmaceutical drug within cells.
Specialized beta cells in the pancreas release the hormone insulin to control our blood glucose levels, and failure of this mechanism is central to the development of type-2 diabetes. How much and when insulin is released depends on a complex system of messenger molecules and proteins that is not well understood.
Time periods by calendar related to perceived stress are associated with the incidence rate of myocardial infarction (MI), says a new nationwide registry study of the Swedish population. Compared to control days, the daily incidence rate of MI was higher during the winter holidays, and on Mondays, whereas rates were lower during weekends and during the summer vacation in July.
Synchrotron scanning can produce high-quality 3D models of well-preserved food residues from fossil faeces. That's the result of a new study, by palaeontologists from Uppsala University and from ESRF Grenoble, which is presented in a new article in Scientific Reports.
One in five people dreams of publishing a novel. At the same time, there are no hard and fast criteria for determining whether a manuscript has the proper traits for publication by an established publisher. This creates a fundamental insecurity among both aspiring writers and publishers alike, according to a new dissertation from Uppsala University.
Why has the neoclassical Gustavian style become so prominent in the Swedish self-image? A new dissertation from Uppsala University shows how researchers in art history, along with museums, commercial enterprises and the monarchy, have contributed to preserving and conveying the Gustavian style.
A new study from Uppsala University in Sweden has indicated that the norm-conscious practices used by teachers at preschools termed “gender-neutral” are associated with reductions in children’s tendencies to make gender-stereotypical assumption. The practices are also associated with children’s increased interest in playing with unfamiliar peers of the opposite sex.
Achieving magnetic order in low-dimensional systems consisting of only one or two dimensions has been a research goal for some time. In a new study published in the journal Nature Communications, Uppsala researchers show that magnetic order can be created in a two-dimensional chessboard lattice consisting of organometallic molecules that are only one atomic layer thic
A drop of blood on filter paper, allowed to dry and stored for future diagnostic purposes – considerably easier than the present-day, resource-consuming method using frozen blood samples in plastic tubes. In a new study, Uppsala researchers measured 92 different proteins in dried samples and show the method has great potential to save resources, to the benefit of early diagnostics and treatment.
