Mutations in the neurochondrin (NCDN) gene can cause epilepsy, neurodevelopmental delay and intellectual disability. The gene mutation significantly impairs contacts and signalling between neurons in the brain. This is the conclusion of a study led from Uppsala University and published in the American Journal of Human Genetics.
Mantle cell lymphoma is a malignant disease in which intensive treatment can prolong life. In a new study, scientists show that people with mantle cell lymphoma who were unmarried, and those who had low educational attainment, were less often treated with a stem-cell transplantation, which may result in poorer survival. The findings have been published in the scientific journal Blood Advances.
In asthma, the airways become hyperresponsive. Researchers from Uppsala University have found a new mechanism that contributes to, and explains, airway hyperresponsiveness. The results are published in the scientific journal Allergy.
Researchers at Uppsala University have developed a digital self-test that trains users to assess news items, images and videos presented on social media. The self-test has also been evaluated in a scientific study, which confirmed the researchers’ hypothesis that the tool genuinely improved the students’ ability to apply critical thinking to digital sources.
Antimicrobial resistance is an urgent global threat to human and animal health. This year’s Uppsala Health Summit, which will take place online on 15–18 March, will discuss how behaviour change across various sectors of society can slow down this worrying trend.
Recent results from Uppsala University and Karolinska Institutet demonstrate that self-collected blood in the form of dried blood spots works well in analyses of protein biomarkers for cardiovascular disease. Using these types of samples would mean simpler and efficient blood collection that could be done by the individuals themselves.
Using theoretical models of bacterial metabolism and reproduction, scientists can predict the type of resistance that bacteria will develop when they are exposed to antibiotics. This has now been shown by an Uppsala University research team, in collaboration with colleagues in Cologne, Germany. The study is published in the journal Nature Ecology and Evolution.
When and how bone marrow first originated in the limbs of early four-legged animals is disputed in evolutionary biology. With the help of powerful X-ray technology, an international research team, led by Uppsala University, has now discovered that this evolutionary adaptation most likely took place after the first tetrapods stepped ashore. The study is published in the scientific journal eLife.
Researchers at Uppsala University have created the first 3D map of the hearing nerve showing where the various sound frequencies are captured. Using what is known as synchrotron X-ray imaging, they were able to trace the fine nerve threads and the vibrating auditory organ, the cochlea, and find out exactly how the frequencies of incoming sound are distributed.
Propranolol, a drug that is efficacious against infantile haemangiomas (“strawberry naevi”, resembling birthmarks), can also be used to treat cerebral cavernous malformations, a condition characterised by misshapen blood vessels in the brain and elsewhere. This has been shown by researchers at Uppsala University in a new study published in the scientific journal Stroke.
In patients with severe COVID-19, the innate immune system overreacts. This overreaction may underlie the formation of blood clots (thrombi) and deterioration in oxygen saturation that affect the patients. This is shown in an Uppsala University study published in the journal Frontiers in Immunology.
The effects of the endocrine disruptor linuron on frogs are not limited to those exposed, but are passed on to their offspring (reduced body weight and decreased fertility) and grand-offspring (increased body weight and a disrupted metabolism). This is demonstrated by a new study (Uppsala University and Stockholm University), published in the journal Science of the Total Environment.
Researchers from Uppsala University show in a new study that inhibition of the protein EZH2 can reduce the growth of cancer cells in the blood cancer multiple myeloma. The reduction is caused by changes in the cancer cells’ metabolism. These changes can be used as markers to discriminate whether a patient would respond to treatment by EZH2 inhibition.
Hydrogen for energy use can be extracted in an environmentally friendly way from water and sunlight, using photocatalytic composite polymer nanoparticles developed by researchers at Uppsala University. In laboratory tests, these “polymer dots” showed promising performance and stability alike. The study has been published in the Journal of the American Chemical Society.
Researchers at Uppsala University and the Swedish University of Agricultural Sciences have used new methods for DNA sequencing and annotation to build a new, and more complete, dog reference genome. This tool will serve as the foundation for a new era of research, helping scientists to better understand the link between DNA and disease, in dogs and in their human friends.
Higher blood pressure at night than in daytime may be a risk factor for Alzheimer's disease in older men. This is suggested by a new study from researchers at Uppsala University, now published in the journal Hypertension.
The molecular details of how SARS-CoV-2 enters cells and infects them are still not clear. Researchers at Uppsala University have tested the bioinformatic predictions made by another research group and have identified receptors that could be important players in the process. The results are presented in the journal Science Signaling and at the AAAS Annual Meeting held this week.
Stefania Barca, from the University of Coimbra in Portugal, is to be Uppsala University’s fourth Zennström Professor of Climate Change Leadership. In her research, she focuses particularly on issues of justice connected with environmental and climate change.
People receiving treatment for cancer are known to feel better with physical training. But does it make any difference how vigorously they exercise? A new study by researchers at Uppsala University shows that whether the training is intensive or rather less strenuous, its effect is roughly the same. The results are published in the journal Scandinavian Journal of Medicine and Science in Sports.
A warmer global climate can cause mutations to have more severe consequences for the health of organisms through their detrimental effect on protein function. This may have major repercussions on organisms’ ability to adapt to, and survive in, the altered habitats of the future. This is shown in a new Uppsala University research study.
