Blood vessels

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Blood vessels

Platelets are activated in blood vessels in wounds but also in tumour blood vessels. The study proves that PDGFB released from platelets, when activated, plays an essential role in attracting supporting cells to the blood vessels and in preventing tumour cells from spreading.
Yanyu Zhang
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Yanyu Zhang
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  • The image shows platelets (red) in close contact with tumor vessels (green). Platelets are activated in the tumour microenvironment and secrete a large number of growth factors. Credit: Yanyu Zhang

    Novel function of platelets in tumour blood vessels found

    Scientists at Uppsala University have discovered a hitherto unknown function of blood platelets in cancer. In mouse models, these platelets have proved to help preserve the vascular barrier which makes blood-vessel walls selectively impermeable, thereby reducing the spread of tumour cells to other parts of the body. The study is published in the journal Cancer Research.

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