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Platelets and tumour blood vessels

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Platelets and tumour blood vessels

The image shows platelets (red) in close contact with tumour vessels (green). Platelets are activated in the tumour microenvironment and secrete a large number of growth factors. Conditional knockout of PDGFB in platelets demonstrates its previously unknown role in pericyte recruitment, maintenance of tumour vascular integrity and host protection against metastasis.
Yanyu Zhang
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Yanyu Zhang
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  • The image shows platelets (red) in close contact with tumor vessels (green). Platelets are activated in the tumour microenvironment and secrete a large number of growth factors. Credit: Yanyu Zhang

    Novel function of platelets in tumour blood vessels found

    Scientists at Uppsala University have discovered a hitherto unknown function of blood platelets in cancer. In mouse models, these platelets have proved to help preserve the vascular barrier which makes blood-vessel walls selectively impermeable, thereby reducing the spread of tumour cells to other parts of the body. The study is published in the journal Cancer Research.