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Schematic figure of the fusidic acid resistance “stop-motion” movie

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Schematic figure of the fusidic acid resistance “stop-motion” movie

Schematic figure of the fusidic acid resistance “stop-motion” movie. On the left, the protein EF-G (green) is locked to the ribosome (light blue and white) by the antibiotic fusidic acid (dark blue). In the middle, FusB (pink) binds and breaks EF-G off the ribosome, which releases fusidic acid. On the right, the rescued ribosome is ready to resume protein synthesis.
Maria Selmer
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Maria Selmer
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  • Schematic figure of the fusidic acid resistance “stop-motion” movie.

    New molecular movie reveals how antibiotic resistance to fusidic acid works

    Researchers from Uppsala Antibiotic Center, Uppsala University and SciLifeLab describe a fundamental mechanism of antibiotic resistance. What happens in a bacterium that is resistant to the antibiotic fusidic acid? With a stop-motion movie at the atomic level, they can show that the resistance protein FusB works nearly like a crowbar. Article published in Nature Communications