Image - 7 August 2024

Tobias Sjoblom.jpg

Tobias Sjöblom, professor at the Department of Immunology, Genetics and Pathology at Uppsala University.

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Genetic signatures provide prognostic information in colorectal cancer

Using a unique collection of genetic and clinical data for colorectal cancer, researchers at Uppsala University have revealed genetic new alterations and developed of a new molecular classifier of tumour variants. The finding could lead to improved possibilities for individualised therapies. This is shown in study recently published in the journal Nature.

A graphical summary illustrates the strategy used to identify CYP2D6 as a target for collateral lethality, which is driven by the widespread occurrence of loss of heterozygosity in cancer genomes.

14 November 2024 07:00

Genetic variation enhances cancer drug sensitivity

By exploiting the genetic variation in cancer cells, an already approved cancer drug demonstrated enhanced effects against cancer cells in specific patient groups. This is shown in a recent study from Uppsala University, published in the journal eBiomedicine. The findings suggest a potential for more individually tailored and more effective cancer therapies.