Many pharmaceuticals work by targeting what are known as “G-protein-coupled receptors”. In a new study, scientists from Uppsala University describe how they have been able to predict how special molecules that can be used in new immunotherapy against cancer bind to these receptors.
New data from the Uppsala Conflict Data Program (UCDP), Uppsala University, shows that the number of fatalities in organised violence continues to decrease. The declared defeat of Islamic State (IS) in Syria and Iraq has pushed the number of fatalities to its lowest level since the outbreak of the Syrian civil war in 2011. However, peace researchers are worried about recent trends in Africa.
A research team at Uppsala University has resurrected several billion-year-old enzymes and reprogrammed them to catalyse completely different chemical reactions than their modern versions can manage. The method can be used to develop sustainable solutions within biotechnology, such as for enzyme bioreactors or to chemically degrade environmental toxins.
Researchers at Uppsala University have developed a method for identifying functional mutations and their effect on genes relevant to the development of glioblastoma – a malignant brain tumour with a very poor prognosis. The study is published in Genome Biology.
In previous research, it has been assumed that insects in temperate regions would cope well with or even benefit from a warmer climate. Not so, according to researchers from the Universities of Uppsala and Lund in Sweden and Oviedo, Spain, in a new study. The earlier models failed to take into account the fact that insects in temperate habitats are inactive for much of the year.
What kind of interactions did the various Stone Age cultures have with one another? In a new interdisciplinary study, researchers have combined archaeological and genetic information to better understand Battle Axe cultural influences discovered in graves of the Pitted Ware culture. The findings are published in the American Journal of Physical Anthropology.
Researchers at Uppsala University and Uppsala University Hospital have developed a new method to measure levels of the medication hydroxychloroquine in patients with the rheumatic disease systemic lupus erythematosus (SLE). The analysis method may also be useful in other areas, such as in the treatment of COVID-19. The study is being published in Arthritis Research and Therapy.
Enzymes from cold-loving organisms that live at low temperatures, close to the freezing point of water, display highly distinctive properties. In a new study published in Nature Communications, scientists at Uppsala University have used large-scale computations to explain why many cold-adapted enzymes stop functioning at around room temperature.
The organ of balance in the inner ear is surrounded by the hardest bone in the body. Using synchrotron X-rays, researchers at Uppsala University have discovered a drainage system that may be assumed to play a major role in the onset of Ménière's disease, a common and troublesome disorder. These results are published in the journal Scientific Reports.
Without a wife and a well-functioning household, Carl Linnaeus would have had difficulty becoming the prominent scientist that he was. Mastering social codes, like clothing and hosting guests for dinners, was crucial for having a career in the 18th century. These are the conclusions of a recently defended thesis at Uppsala University.
Patients taking part in clinical trials do not receive better treatment than other patients. This is the conclusion of a new study led from Uppsala University and published in peer-reviewed journal BMC Cancer, which confirms the results of an earlier study from 2004.
Despite the traditional view that species do not exchange genes by hybridisation, recent studies show that gene flow between closely related species is more common than previously thought. A team of scientists from Uppsala University and Princeton University now reports how gene flow between two species of Darwin’s finches has affected their beak morphology.
