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Topics: Epidemics

New antibody could be promising cancer treatment

New antibody could be promising cancer treatment

Researchers at Uppsala University and KTH Royal Institute of Technology have developed a new form of precision medicine, an antibody, with the potential to treat several types of cancer. Researchers have managed to combine three different functions in the antibody, which together strongly amplify the effect of T cells on the cancer tumour. The study has been published in Nature Communications.

Bank voles in Skåne carry a virus that can cause hemorrhagic fever in humans. Photo: B. Niklasson

Vole fever spreading further south

Researchers have discovered that bank voles in Skåne, southern Sweden, carry a virus that can cause hemorrhagic fever in humans. This finding was made more than 500 km south of the previously known range. This is revealed in a new study from Uppsala University. The researchers were surprised that such a high proportion of the relatively few voles they caught were actually carrying a hantavirus.

Camilla Sköld, Specialist Physician in Gynaecological Cancer at the Oncology Clinic, Uppsala University Hospital, researcher at Uppsala University. Photo: Anthoula Koliadi

Lower survival rates for women than men with germ cell tumours

Women with a type of ovarian cancer known as germ cell tumours have a worse prognosis than men with similar tumours, i.e. testicular cancer. After five years with the disease, 98 percent of men were alive while the survival rate for women was only 85 percent. This has been revealed by a new study from Uppsala University and Uppsala University Hospital published in the Journal of Internal Medicine.

Distance education during pandemic led to less care for mental ill health

Distance education during pandemic led to less care for mental ill health

Upper secondary school students were less likely to seek help for mental ill health when they were forced to study at home during the pandemic. A similar decrease was not seen for secondary school students aged 14–16 who remained in school. This has been shown in a new study at Uppsala University, based on data covering all of Sweden's upper secondary school students between 2015–2021.

More mast cell progenitors during pollen season

More mast cell progenitors during pollen season

The frequency of mast cell progenitors in the blood circulation is higher in asthma patients during the birch pollen season than outside of it. This has been demonstrated in a new study by Uppsala University, published in the scholarly journal Allergy.

Difficult decisions led to unequal vaccination rates

There was a significant difference in the speed with which different groups were vaccinated against COVID-19. One explanation could be that people absorb information and make decisions in different ways. A new study shows that among people with the highest cognitive ability, 80% had been vaccinated within 50 days. Among those with the lowest cognitive ability, it took 180 days to achieve the same

Newly discovered coronavirus common in bank voles

Researchers from the Zoonosis Science Center at Uppsala University have identified a new coronavirus. Their study of approximately 260 bank voles caught around Grimsö, Örebro County, shows that the virus is well established in Sweden’s red-backed voles. The finding has been published in the journal Viruses.

Symptom data help predict COVID-19 admissions

Symptom data help predict COVID-19 admissions

In COVID Symptom Study Sweden more than 10 million daily reports from participants in COVID Symptom Study Sweden from April 2020 to February 2021. The scope of the study was to develop and evaluate a framework to estimate the regional prevalence of COVID-19 using symptom-based surveillance, and to test if these prevalence estimates could be used to predict subsequent trends in COVID-19 admissions.

Blocking inhibits SARS-CoV-2 infection of human cells

Blocking inhibits SARS-CoV-2 infection of human cells

Researchers have developed and used a new method to map interactions on a large scale between human proteins and coronavirus proteins, which has provided valuable new information. In collaborations with others, they show that blocking one of these interactions inhibited infection of human cells by SARS-CoV-2. They also confirmed the interaction between the viral protein and the human protein.

Jordi Carreras-Puigvert and Jonne Rietdijk studying cell images being acquired by a high-content microscope. Photo: Uppsala University

Method for discovery of antiviral drugs

The current COVID-19 pandemic has highlighted the need for methods to identify new or repurposed drugs as antivirals. Researchers at Uppsala University and Karolinska Institutet are now presenting a new screening approach that focuses on the identification of virus-specific morphological changes in virus-infected cells.

The Leap Health Breakthrough Network, Wellcome Leap.

​Uppsala University Joins Wellcome Leap Global Network

Uppsala University has joined the Leap Health Breakthrough Network, a global group of 21 leading academic and research institutions committed to solving the world’s most serious health challenges — such as cancer and infectious diseases — at record speed. Wellcome Leap is a US-based non-profit organisation founded by the Wellcome Trust to accelerate innovations that benefit global health.

Nitric oxide a possible treatment for COVID-19

Researchers at Uppsala University have found that an effective way of treating the coronavirus behind the 2003 SARS epidemic also works on the closely related SARS-CoV-2 virus, the culprit in the ongoing COVID-19 pandemic. The substance concerned is nitric oxide (NO), a compound with antiviral properties that is produced by the body itself. The study is published in the journal Redox Biology.

Possible blood-clotting mechanism in COVID-19 found

Why so many COVID-19 patients get blood clots (thrombosis) remains uncertain. But scientists at Uppsala University and the University Hospital have now identified a mechanism they believe to be implicated. A particular protein triggers a part of our immune system that can boost the blood’s tendency to coagulate and form clots. The study is now published in Thrombosis and Haemostasis.

New insight about how viruses use host proteins to their advantage

Viruses have a very limited set of genes and therefore must use the cellular machineries of their hosts for most parts of their growth. A new study, led by scientists at Uppsala University, has discovered a specific host protein that many viruses use for their transport within the cell. The discovery opens up new possibilities to develop a broad spectrum anti-viral therapy.

Report Uppsala Health Summit: 100 years after the Spanish flu – how can we protect ourselves against new epidemics?

Warding off the threats of future epidemics will be difficult without better cooperation and contingency plans that allow us to act before a crisis hits. This is one message in a new report summarising the discussions of the Uppsala Health Summit on the theme of Tackling Infectious Disease Threats: Prevent, Detect and Respond with a One Health Approach, which took place in October last year.

Threats from infectious diseases on Uppsala Health Summit agenda

At the Uppsala Health Summit Tackling Infectious Disease Threats, due to start next week, experts and decision makers from ministries, academia, companies and voluntary organisations are meeting to discuss how jointly to reduce the risk of severe outbreaks.

Infectious disease threats in focus at Uppsala Health Summit 2017

Despite remarkable gains in health over the last century, infectious diseases remain a major threat. Alarming reports on outbreaks of Zika, Ebola or avian flu serve as reminders of the gravity of the situation. At the high-level meeting Uppsala Health Summit, international experts will gather from different sectors to discuss how to reduce the threats.

Childhood obesity in focus at 2016 Uppsala Health Summit

In just a few decades, the number of overweight and obese adults and children in the world has reached alarming levels, not least in low-income countries. This year, Uppsala Health Summit is taking place in conjunction with World Obesity Day: 11-12 October 2016. International experts on child obesity will gather to discuss countermeasures with industry, policy makers and society.

Malaria testing yet to reach its potential

In a study published this month in Malaria Journal, researchers from Uppsala University and other institutions present a new model for systematically evaluating new malaria treatment programs in routine conditions across multiple countries.

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