More cases of colorectal cancer are detected at an early stage with screening. This is according to new research based on data from over 278,000 60-year-olds, who were randomly selected to undergo one of two interventions or no screening at all (usual care). The study, which is a collaboration between Uppsala University and Karolinska Institutet, has been published in Nature Medicine.
The malignant pediatric brain tumor medulloblastoma is driven by proteins deep within the cancer cells, for which there are often no effective drugs available. Researchers at Uppsala University have identified a new genetic technique that enables targeting of tumour cells with elevated levels of such proteins. The technique could be used to eliminate cells responsible for tumour relapse.
Some common hormonal contraceptives are linked to a slightly higher risk of breast cancer than others. This is shown by a new Swedish study from Uppsala University, in which researchers followed more than two million women and teenage girls in Sweden to identify how different hormonal contraceptives affect the risk of breast cancer.
AI can be used to detect cervical cancer in women in resource-limited parts of the world. However, for this method to work, investments are needed in healthcare staff, reliable supply chains and trust in these communities.
Men assessed as healthy after a pathologist analyses their tissue sample may still have an early form of prostate cancer. Using AI, researchers at Uppsala University have been able to find subtle tissue changes that allow the cancer to be detected long before it becomes visible to the human eye.
In the largest Nordic study to date concerning oesophageal cancer surgery, the researchers found clear evidence that decompression with a nasogastric tube is associated with less serious complications. Their results challenge a trend of declining use of the nasogastric tube after major surgical procedures.
Researchers at Uppsala University have identified a promising therapeutic approach for the challenging blood cancer multiple myeloma. In a new preclinical study, they demonstrate that a dual treatment with drugs that inhibit epigenetic regulation reduces tumour growth and induces cancer cell death.
An international research team led from Uppsala University has identified new mechanisms behind how the aggressive brain tumour glioblastoma spreads in the brain. Targeting the identified connection between the tumour invasion routes and the tumour cell states could be a potential new treatment strategy.
Most men who are treated for prostate cancer according to modern guidelines have good survival rates and the majority of these men will die of causes other than prostate cancer. This is revealed in a new study from Uppsala University published in the Journal of the National Comprehensive Cancer Network. "“We were surprised by how much life expectancy affected the prognosis" says Marcus Westerberg.
That fit people have a reduced risk of premature death from various diseases is a recurring result in many studies. New research from Uppsala University shows that people with high fitness levels in their late teens also have a reduced risk of dying from random accidents. This suggests that the associations seen in previous studies have probably been misleading.
A recent study shows that the Semliki Forest virus enters the central nervous system by first entering the cerebrospinal fluid and then binding to a specific cell type before penetrating deeper into the brain. This finding could potentially be used to develop the Semliki Forest virus as an agent for treating brain cancer. The study has been published in the journal Nature Communications.
By exploiting the genetic variation in cancer cells, an already approved cancer drug demonstrated enhanced effects against cancer cells in specific patient groups. This is shown in a recent study from Uppsala University, published in the journal eBiomedicine. The findings suggest a potential for more individually tailored and more effective cancer therapies.
Researchers at Uppsala University and KTH Royal Institute of Technology have developed a new form of precision medicine, an antibody, with the potential to treat several types of cancer. Researchers have managed to combine three different functions in the antibody, which together strongly amplify the effect of T cells on the cancer tumour. The study has been published in Nature Communications.
The survival rate of men with prostate cancer who had their entire prostate gland removed immediately after the tumour was detected increased by 17 percentage points compared with those who did not have treatment until the tumour began to cause symptoms. On average, they also lived more than two years longer. These are the final results of a 30-year Scandinavian study led from Uppsala University.
A new treatment for locally advanced rectal cancer shows favourable results in that surgery can sometimes be avoided completely. It also reduces the risk of recurrence. The method has been confirmed as effective in a comprehensive study conducted at Uppsala University and published in eClinicalMedicine.
Using a unique collection of genetic and clinical data for colorectal cancer, researchers at Uppsala University have revealed genetic new alterations and developed of a new molecular classifier of tumour variants. The finding could lead to improved possibilities for individualised therapies. This is shown in study recently published in the journal Nature.
Every year, around 100 people are affected by mantle cell lymphoma. A study at Uppsala University shows that these patients are more vulnerable to other diseases and that the risk of infection for this type of patient should therefore be carefully evaluated. The results of the study have been published in the journal Hemasphere.
Women with a type of ovarian cancer known as germ cell tumours have a worse prognosis than men with similar tumours, i.e. testicular cancer. After five years with the disease, 98 percent of men were alive while the survival rate for women was only 85 percent. This has been revealed by a new study from Uppsala University and Uppsala University Hospital published in the Journal of Internal Medicine.
The nuclear accident in Chernobyl in 1986 led to the spread of radioactivity across Sweden and Europe. In a long-term study now published in Environmental Epidemiology, researchers have used new, more specific calculation methods to show the connection between radiation dose and certain types of cancer.
Survival rates for men with metastatic prostate cancer have increased by an average of six months, something which coincides with the gradual introduction of ‘dual treatment’ since 2016. This is according to a register study of all Swedish men diagnosed between 2008 and 2020. The results are published in the medical journal JAMA Network open.